Title: Study of Serum Lipid Profile in Beta-Thalassemia Major Patients
Authors: Dr Suraj Doshi, Dr N.R. Sutay
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.71
Abstract
Objectives
1. To assess the Serum Lipid Profile of patients with Beta-Thalassemia Major.
2. Comparison of the Serum lipid profile of Beta-thalassemia major patients with healthy children.
Study Design: This was a cross sectional case control study in which 100 diagnosed cases of Beta thalassemia major were enrolled. 100 healthy children of same age group consisted of control group. The blood samples of study and control groups were examined for lipid profile test and values were evaluated. The tests were done using Olympus AU400 Auto analyser and values were evaluated. Statistical analysis was done by using IBM SPSS version 20.
Results: Mean age of cases was 9.04 ± 4.11 years and of controls was 8.92 ± 4.0 years. The mean values of serum HDL-C, LDL-C, total cholesterol, TG and VLDL in cases were 26.5±8.9, 62.1±21.9, 111.8 ±26.7, 112.06±53.40, 25.58±21.15 mg/dl respectively. Moreover, the mean values of serum HDL-C, LDL-C, total cholesterol, TG and VLDL in controls were 47.6±4.3, 76.8 ±15.4, 76.8 ±15.4, 74.64±16.23, 22.63±6.6715 mg/dl respectively. Total-cholesterol to HDL-C ratio was4.57±1.55 and 2.66±0.39 in cases and controls respectively. Total cholesterol, HDL-C, LDL-C were significantly lower (p<0.05); triglycerides and total cholesterol & HDL ratio were significantly higher (p<0.05) compared with controls.
Conclusion: Beta thalassemia major patients have hypertriglyceridemia and hypocholesterolemia. This study concludes that children suffering from beta thalassemia major may possess increased risk of thrombotic and atherogenic complications. Early detection of these patients with deranged lipid profile is required to avoid these complications. It is also important to do routine periodical screening.
Keywords: Beta Thalassemia Major, Lipid Profile, Hypocholesterolemia, hypertriglyceridemia, Thromboembolism.
References
1. Louis C.K. Low. Growth of children with beta thalassemia major. Indian J Pediatr 2005 Feb; 72:159- 160.
2. Verma IC, Choudhry VP, Jain PK. Prevention of thalassemia: A necessity in India. Indian J Pediatr 1992; 59: 649-654.
3. Agarwal, S., A. Gupta, U. R. Gupta, S. Sarwai, S. Phadke, and S. S. Agarwal. "Prenatal diagnosis in beta-thalassemia: an Indian experience." Fetal diagnosis and therapy 18, no. 5 (2003): 328-332.
4. Modell, Bernadette, and Matthew Darlison. “Global Epidemiology of Haemoglobin Disorders and Derived Service Indicators.” Bulletin of the World Health Organization 86.6 (2008): 480–487. PMC. Web. 14 Dec. 2014.
5. Madan, N., Sharma, S., Sood, S. K., Colah, R., & Bhatia, (Late) H. M. (2010). Frequency of β-thalassemia trait and other hemoglobinopathies in northern and western India. Indian Journal of Human Genetics, 16(1), 16–25. doi:10.4103/0971-6866.64941
6. Galanello R, Eleftheriou A, Traeger-Synodinos J, Old J, Petrou M, Angastiniotis M. In: Princeton of Thalassaemias and other Haemoglobin-opathies. 2003. Annex 1: Global epidemiological data tables; pp. 148–53.
7. Yaish HM. Thalassemia. http:// www.emedicine.com/PED/topic2229.htm Accessed as on date 6th August 2013.
8. Verma IC, Choudhry VP, Jain PK. Prevention of thalassemia: A necessity in India. Indian J Pediatr 1992; 59: 649-654.
9. Roberts D.J., Brunskill S.J., Deree C. Oral Deferiprone for Chelation in children with Thalassemia. National Blood Service, Systematic Review Initiative, UK OX3 9BQ.
10. Grow, Kirti, MinakshiVashist, PankajAbrol, Shiksha Sharma, and RituYadav. "Beta Thalassemia in India: Current Status and the Challenges Ahead." International Journal of Pharmacy & Pharmaceutical Sciences 6, no. 4 (2014).
11. Arıca, Vefik, Seçil Arıca, CahitÖzer, and Murat Çevik. "Serum Lipid Values in Children with Beta Thalassemia Major." PediatTherapeut 2, no. 130 (2012): 2161-0665.
12. Shamshirsaz, Alireza A., Mir Reza Bekheirnia, Mohammad Kamgar, Nima Pourzahedgilani, NavidBouzari, Moha-mmadreza Habibzadeh, Reza Hashemi et al. "Metabolic and endocrinelogic complications in beta-thalassemia major: a multicenter study in Tehran." BMC Endocrine Disorders 3, no. 1 (2003): 4.
13. Omran, DakhelGhani. "Lipid Profile in Children with Beta–Thalassemia Major in Babylon."
14. Al-Quobaili, Faizeh A., and Imad E. AbouAsali. "Serum levels of lipids and lipoproteins in Syrian patients with beta-thalassemia major." Saudi medical journal 25, no. 7 (2004): 871-875.
15. Mansi, Kamal M., and Talal A. Aburjai. "Lipid Profile in Jordanian Children with ß-thalassemia Major." International Journal of Hematology and Oncology 18 (2008): 93-98.
16. Patne, A. B., P. J. Hisalkar, and S. B. Gaikwad. "Lipid Abnormalities in Patients of Beta Thalassaemia Major. "IJPBS, vol(2),issue 2,April-June(2012);106-112
17. Arıca, Vefik, Seçil Arıca, CahitÖzer, and Murat Çevik. "Serum Lipid Values in Children with Beta Thalassemia Major." PediatTherapeut 2, no. 130 (2012): 2161-0665.
18. Khubchandani, Asha, Viral Solanki, VijaysinhParmar, Meghana Solanki, Jaimin Patel, and SagarGangwani. "Estimation of Serum lipid profiles in patients with Beta-thalassemia major."
19. KhaleedJumaa K., Abeer A.A., MaysemM.Alwash, Nahi Y. Yaseen, Ahmed M.Hamza “Biomarkers and trace elements in beta thalassemia major.” Iraqi Journal of Cancer and Medical Genetics.
20. Maioli, M., G. B. Cuccuru, P. Pranzetti, A. Pacifico, and G. M. Cherchi. "Plasma lipids and lipoproteins pattern in beta-thalassemia major." Actahaemat-ologica 71, no. 2 (1984): 106-110.
21. Maioli, Mario, Silvestro Pettinato, Gian Mario Cherchi, DomenicoGiraudi, Adolfo Pacifico, Giuseppe Pupita, and Massimo GB Tidore. "Plasma lipids in beta-thalassemia minor." Atherosclerosis 75, no. 2 (1989): 245-248.
22. Maioli, Mario, Giovanni B. Vigna, Giancarlo Tonolo, PatriziaBrizzi, MilcoCiccarese, Paola Donegà, MargheritaMaioli, and Renato Fellin. "Plasma lipoprotein composition, apolipoprotein (a) concentration and isoforms in<i> β</i>-thalassemia." Ather-osclerosis 131, no. 1 (1997): 127-133.
23. Christina C, Demosthenes B, Christos P. Distributionof serum lipids and lipoproteins in patients with beta thalassemia major; an epidemiological study in young adults from Greece.Lipids in Health and Disease 3: 328-334, 2004.
24. Goldfarb AW, Rachmilewitz EA, Eisenberg S. Abnormal low and highdensity lipoproteins in homozygous beta-thalassaemia. Br J Haematol. 1991;79:481-486.
25. Amendola, G., P. Danise, N. Todisco, G. D'urzo, A. Di Palma, and R. Di Concilio. "Lipid profile in β‐thalassemia intermedia patients: correlation with erythroid bone marrow activity." International journal of laboratory hematology29, no. 3 (2007): 172-176.
26. Hartman, Corina, Hannah Tamary, Ada Tamir, Evelyn Shabad, Carina Levine, Ariel Koren, and Raanan Shamir. "Hypocholesterolemia in children and adolescents with β-thalassemia intermedia." The Journal of pediatrics 141, no. 4 (2002): 543-547.
27. Hashemieh, M., M. Javadzadeh, A. Shirkavand, and K. Sheibani. "Lipid profile in minor thalassemic patients: a historical cohort study." Bangladesh Medical Research Council Bulletin 37, no. 1 (2011): 24-27.
28. Shams, Sedigheh, Mohammad TaghiHaghi Ashtiani, Maryam Monajemzadeh, Leili Koochakzadeh, HeshmatIrani, Fahimeh Jafari, and AmenehMohseni. "Evaluation of Serum Insulin, Glucose, Lipid Profile, and Liver Function in β-Thalassemia Major Patients and Their Correlation With Iron Overload." Lab Medicine 41, no. 8 (2010): 486-489
29. Zannos-Mariolea L, Papagregoriou-Theodoridou M, Costantzas N, et al.Relationship between tocopherols and serum lipid levels in children withbeta-thalassemia major. Am J ClinNutr. 1978;31:259–26332.Christina et al
30. Ferdaus, Mohammed Zubaerul, A. K. M. M. Hasan, and Hossain Uddin Shekhar. "Analysis of serum lipid profiles, metal ions and thyroid hormones levels abnormalities in β-thalassaemic children of Bangladesh." JPMA. The Journal of the Pakistan Medical Association 60, no. 5 (2010): 360.
31. Ragab, S. M., M. A. Safan, and A. S. Sherif. "Lipid profiles in β thalassemic children." Menoufia Medical Journal 27, no. 1 (2014): 66.