Title: Correlation of Fetal Hemoglobin (HbF) with Clinical Findings and red cell indices in Thalassemia: ‘Harbinger of HbF Inducer Therapies’
Authors: Sharmila Gupta, Ashok Kumar Kapoor, Vidya Bhushan, Ashutosh Kumar, Upama
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.36
Aim of this study was to correlate the fetal hemoglobin (HbF) values with red cell indices in patients with thalassemia. Present study was done on 9 patients with thalassemia. All the 9 patients belonged to Tharu Chaudhary community and hailed from mid-western region of Nepal. Thirteen subjects with abnormal hemoglobin structure acted as disease-controls. Eight other subjects with normal hemoglobin structure were also taken as disease-controls. All the subjects (n = 30) included in this study had microcytic hypochromic anemia. Venous blood was collected from all the patients. Blood cells were washed and lysed. Later, Hb electrophoresis was done. Hb electrophoresis revealed presence of HbF in blood of 8 of 9 thalassemic patients. HbF values ranged from 2% to 96% in patients. HbF was inversely correlated with MCHC and MCV. HbA2 was also correlated with Hct and RBC. Findings of this study suggested that rise in HbF in thalassemic patients may improve hypochromia and thus may favor survival of red cells.
Dr Ashok Kumar Kapoor D87 Mahanagar Extension, Vigyan Puri, Lucknow, Uttar Pradesh, India-226006 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.Abstract