Title: Comparison of Intravenous Paracetamol and Intraperitoneal Instillation of 0.25% Bupivacaine with Dexamethasone for Postoperative Analgesia in Patients Undergoing Laparoscopic Sterilisation – A Randomized Clinical Trial
Authors: Dr M. Ravikumar M.D, D.A, Dr Padmanabhan. K.R, M.D, D.A, Dr K. Sivabalakumaran
DOI: https://dx.doi.org/10.18535/jmscr/v10i8.07
Abstract
Background: Intraperitoneal instillation of local anaesthetic as a postoperative analgesia following laparoscopic sterilization is an easy technique which doesn’t need expert hands or specialised equipment and can even be followed in rural centres where sterilisation is performed.
Aim: To study the efficacy and compare intravenous paracetamol with intraperitoneal instillation of 0.25% bupivacaine with dexamethasone during laparoscopic sterilisation for postoperative analgesia.
Methodology: Patients were randomly divided into 2 groups, Group 1(n= 20) - received 100ml of intravenous Paracetamol and Group 2 (n= 20) - received 20ml of 0.25% bupivacaine with dexamethasone (8mg) for intraperitoneal instillation. Patients weighing between 50-70 kg, willing to give written informed consent and assessed under ASAPS I and II are included in this study. Outcome measures will be assessed from baseline and at 0, 1, 2, 4, 8 and 12hrs after the procedure at hospital.
Result: At 8 hours and 12 hours, the mean VAS score was high in group 1 (2.3+0.94), (3+0.94) followed by group 2 (0.4+0.51), (1.1+0.99) respectively which was statistically significant.
Conclusion: This study infers that intraperitoneal instillation of 0.25% bupivacaine with dexamethasone as postoperative analgesia following laparoscopic sterilization is effective in comparison with intravenous Paracetamol.
Keywords: Intraperitoneal instillation, laparoscopic sterilization, postoperative analgesia, intravenous paracetamol, bupivacaine, dexamethasone.