Abstract
Background: Thyroid disorders are common clinical problem which are unique in both clinical presentation and symptoms. Imprint cytology is a simple, inexpensive and rapid diagnostic procedure that can be used in the perioperative diagnosis of thyroid lesions. The current study is designed to study the age, sex profile and the spectrum of various thyroid lesions and to assess the efficacy of imprint cytology by comparing it with histopathology smears.
Method: In our study, conducted over a period of 18 months, imprint cytology of thyroid lesions was done perioperatively. The histopathological diagnosis was considered as the gold standard and imprint cytological diagnosis was compared with it.
Results: In the present study, age of the patient ranged from 14-70 years, with a mean age being 39.24 years. Majority of patients were females with male to female ratio of 1:7.8. Out of the 53 cases studied, 46 cases were diagnosed as benign and7cases were diagnosed as malignant on imprint cytology. On histopathological examination, 45cases were diagnosed as benign and 8 cases were diagnosed as malignant. On cytohistopathological correlation, sensitivity and specificity was found to be 87.5 % and 100% respectively. The positive predictive value, negative predictive value and diagnostic accuracy was found to be 100%, 97.8% and 98.1% respectively.
Conclusion: Imprint cytology is a simple, cost effective and rapid intraoperative diagnostic technique which can be a useful guide in making intraoperative therapeutic decision quickly.
Keywords: Thyroid, Imprint cytology, Histopathology, Colloid goitre, Papillary Thyroid Carcinoma, accuracy
References
- Anila K R , Krishna G. Role of imprint cytology in intraoperative diagnosis of thyroid lesions. Gulf J Oncolog 2014;1:73-8
- Chehrei A, Ahmadinejad M, Tabatabaee S A, Hashemi S M, Kianinia M, Fatesh S, et al. Touch imprint and crash preparation and intraoperative cytology versus frozen section in thyroid nodules. J Res Med Sci 2012;17;475-80
- Taneri F, Poyraz A, Salman B, Tekin E, Akuerek N, Bayram O, et al. Using imprint cytology and frozen section in determining the surgical strategies for thyroid pathologies. Endocrine Regulations, June 2001; Vol 35; 71-74
- Sukumar Shaha, A J E Nahar Rahman. Comparative study of imprint cytology and frozen section in the intraoperative diagnosis of thyroid lesions. Bangladesh J of Pathol:2009;24(1):12-15.
- Francis I M, Das D K. Role of FNA, intraoperative cytology and frozen section in the diagnosis of breast lumps and thyroid lesions. Int J Kuwait University Health Sciences Centre. 1999;8:173-82.
- Belleannée G, Verdebout J, Feoli F et al . Role of cytology and frozen sections in the intraoperative examination of the thyroid: Comparison of two experiences. Clin Exp Pathol. 1999;47:273‑77.
- Manafis K. An intraoperative consultation. Usefulness, reason and accuracy of the method. Arch Hell Pathol .1997;11:472-7.
- Shashidar H B, Vani D, Ashwini N S, Sandhya M. Cyto-histological correlative study of thyroid neoplasms by imprint method. Int J Sci Stud 2015:3(6):140-144.
- Faquin WC. The thyroid gland: recurring problems in histologic and cytologic evaluation. Arch Pathol Lab Med. 2008 Apr;132(4):622-32.
- Khalid A, Anwar U I H .Touch imrint cytology versus frozen section as Intraoperative consultation diagnosis. Intern J Pathol.2004;2(2):63-70.
- S Veneti, Toufexi H, Xenitides J et al. Imprint cytology. Acta Cytologica.1996; 40:649-52.
- Ranjan A, Chandoke RK, Chauhan N et al. Oncology, study of tumors by imprint cytology. Indian J Clin Pract. 2013;24:472-77.
Corresponding Author
Anjali P V
Mysore Medical College, Mysore
DOI: https://dx.doi.org/10.18535/jmscr/v9i12.02
