Title: Study of Incidence of Congenital Rubella and cytomegalo virus infections in Children’s, Attending in Tertiary care Hospital at New Delhi
Authors: Dr Ratnesh Kumar, Dr Sima Choudhary, Dr T.P.Yadav
DOI: https://dx.doi.org/10.18535/jmscr/v7i2.110
Abstract
Objective: The present study was undertaken to determine the role of Rubella and cytomegalo virus (CMV) infections of children and pregnant woman.
Materials and Methods: A total of 232 children were screened for suspected Rubella infection and 276 children were screened for CMV infection. A total of 34 asymptomatic pregnant women were screened for CMV and 112 Asymptomatic Pregnant women for Rubella infection. Pregnant woman with obstetric complications were screened for CMV (n=66) and Rubella (n=282). Blood samples from pregnant woman (Asymptomatic and also woman with obstetric problems) and children (suspected of intrauterine infections) were collected and send to laboratories for tests. The samples were tested for Rubella and CMV specific IgM antibodies by CMIA methods.
Results: In children, overall positivity for Rubella and CMV specific IgM antibodies was 3.44% and 12.67% respectively. In asymptomatic Pregnant females Rubella positivity was 0.89%, while with obstetric complication it was 4.96%. IgM antibody positivity in cases of CMV was 8.82% in asymptomatic pregnant woman and 7.57% in woman with obstetric complications.
Conclusion: The study indicated that infection with CMV is more common than the rubella virus. The incidence of rubella infections were decreases in the past few years. Hence, screening for rubella infection may be reserved for women with obstetric complications only. The routine screening for CMV among all antenatal cases is a debatable issue.
Keywords: Cytomegalovirus, congenital infection, IgM antibodies, rubella.
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