Abstract
Introduction: Vitamin D is a product of cholesterol metabolism. One of the most important step of vitamin D production is (conversion of 7-dehydro-cholesterol to active vitamin D is dependent upon exposure to sunlight. The common causes of vitamin D deficiency include advancing age, inadequate exposure to sunlight and chronic hepatic and renal failure. The relation of vitamin D deficiency and diabetes is complex and many studies have suggested that vitamin D deficiency may be related to onset of type II diabetes and adequate vitamin D levels are necessary to reduce inflammation which is a major factor in progression to overt diabetes mellitus. We have conducted this study to know the vitamin D status of individuals with type II diabetes mellitus and compared it with healthy individuals of comparable age groups.
Materials and Methods: This was a case control study carried out in a tertiary care hospital situated in an urban area with an aim to determine the frequency of vitamin D deficiency or insufficiency in patients with type II diabetes mellitus. 50 known cases of type II diabetes were enrolled in this study as cases on the basis of a predefined inclusion and exclusion criteria. Control group comprised of 50 individuals of similar age and physical characteristic. In both these groups detailed history was taken. Investigations like Complete Blood Count, Serum Calcium and Alkaline Phosphatase was done in all the cases. The data was tabulated and analyzed using SPSS 21.0 version software.
Results: The mean weight and Body mass indexes were comparable in both the groups. The mean weight of control group was 63.28 +/- 7.42 kg while in cases group the mean weight was 69.48 +/- 8.72 kg. While mean height in control and cases group was 5.42 +/- 0.082 and 5.36 +/- 0.064 feet respectively. Serum calcium in cases and control groups was 8.24 +/- 0.22 and 8.82 +/- 0.161 while ALP was 96.30 +/- 8.12 and 106.04 +/- 6.12 respectively. 25 (OH) Vit D was found to be 94.36 +/- 7.92 in control group and 76.60 +/- 5.52 in cases group. Individuals with diabetes were found to have a statistically significantly reduced vitamin D levels as compared to individuals in control group.
Conclusion: Patients having type II DM were found to have significantly lower 25 (OH) vitamin D levels. It is essential that patients with type II DM be screened for vitamin D deficiency and if present it should be treatedappropriately.
Keywords: Vitamin D, Alkaline Phosphatase, Type II Diabetes Mellitus, Insulin Resistance.
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Corresponding Author
Dr Eshant Kurnjekar
Resident, Lecturer, Department of Medicine MGM Medical College Aurangabad (MS) India