Abstract

Introduction: Painful bladder syndrome or Interstitial cystitis (IC) is characterized by an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder and presented as urgency, frequency, nocturia, dysuria of more than 6 weeks duration, in the absence of infection or other identifiable causes. This prospective study done in Patients with symptoms of IC to assess the immediate and sustained relief after a weekly instillation for three weeks of treatment with intravesical alkalinized lidocaine and heparin. by Pelvic pain and Urgency/Frequency Valid scale (PUF)

Method: All included patient were assessed and the PUF score is calculated by the questionarre. With all aseptic precaution, solution of 40,000 U heparin +10mL, 2% Lidocaine and 10mL, 8.4% sodium bicarbonate was administered intravesically in patients and kept  for half an hour then patient is allowed to urinate.  the response to treatment was  followed  after one week and PUF score is calculated and same is repeated for 3 consecutive weeks . The percentage of improvement is calculated by the change in PUF score.

Observation: Total 20 patient (M;F -9:11) with mean PUF score is 23.70 shown significant decrease to 4.85(p= <0.001)  after first instillation.  After every instillation, there is constant decrease in PUF score.

Conclusion: It can be concluded that this intravesical therapy has greater symptom relief of painful bladder syndrome who were failing medical therapy by antimuscuranic and alpha blocker for long time.

Keywords: Interstitial cystitis(IC); intravesical; alkalinized lidocaine; heparin.