Title: A Comparative Study of Prostaglandins (Intravaginal PGE1& Intracervical PGE2) with Oxytocin Infusion for Induction of Labour
Authors: Dr Fauzia Shafi, Dr Sipra Singh, Dr Najmun Nisa
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.159
Abstract
Introduction
Induction of labour is the deliberate initiation of labour before spontaneous onset anytime after the period of viability with the aim of delivery per vagina as a matter of urgency either for the foetus or the mother or both. Although smooth muscle contracts when stretched but in pregnancy effective uterine contractions do not begin before term. It is the alteration of the oestrogen- progesterone ratio with appearance of prostaglandins synthesis and building up of oxytocin receptors in the myometrium, decidua’s and placenta. Oxytocin release in spurts from maternal neurohypophysis, acts on the sensitized myometrium and starts the uterine contraction. At the same time the foetal pituitary starts secreting both oxytocin and vasopressin, either as a result of stress or because of a genetically controlled trigger mechanism.). The PGE2 acts mainly in the cervix to enhance uterine contraction and PGI2 protects the vascular endothelium thus ensuring uterine blood flow and proper oxygenation to the foetus during forceful uterine contraction. The increase myometrial contraction leads to rupture of membrane, which in turn augments the production of prostaglandins that help in the final expulsion of the foetus through the fully effaced and dilated cervix.
Aims and Objective
My aim is to study the induction of labour by prostaglandin PGE1 (misoprostol intravaginal), PGE2 (intracervical dinoprostone) & oxytocin infusion separately and to compare among them with
- Mode of delivery
- Induction – delivery interval
- Their rate of success