We report a case of 60 years old male who presented with complains of abdominal pain and multiple episodes of vomiting. Endoscopic examination revealed a 2.5 cm ulcer in second part of duodenum with elevated margins. CECT abdomen revealed a 10 x 10 cm lesion in the head of pancreas with perilesional lymphadenopathy. Pylorus preserving pancreaticoduodenectomy was performed. Histopathology and immunohistochemistry examination confirmed the diagnosis of extra intestinal GIST of pancreas with positivity for CD117 and vimentin. This case further proves that this rare tumor can involve pancreas as the primary site. Therefore emphasis should be to include this rare tumor in the differential diagnosis of pancreatic neoplasm.

Keywords: extra gastrointestinal stromal tumor, pancreas, CD117, vimentin, histopathology.

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Dr Nuzhat Samoon

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