Background: Liver cirrhosis is one of the most common cause of mortality. Among the causes alcoholism leads the first. Several scoring are available for the severity in cirrhosis and hepatic fibrosis. 

Aims and Objectives: 1) To calculate APRI INDEX, child pugh score and MELD score in liver cirrhosis patients. 2) To find the correlation between APRI index, MELD score and Child pugh Score.

Materials and Methods: retrospective study among 50 patients with cirrhosis of liver. Cirrhosis of liver was confirmed by ultrasound and biochemical reports. Cirrhosis due to alcohol, Hepatitis B, Hepatitis C, NAFLD leading to cirrhosis were included in the study. APRI Index, Child Pugh Score, MELD Score were calculated and the correlation was obtained.

Results and Conclusion: The study found out the relationship of MELD Score and Child Pugh Score, and MELD Score and APRI index with significant p value. The study also showed significant p value between APRI Index and Child Pugh Score. The study also showed that raised APRI Index, higher Child Pugh classification and higher MELD score for patients who died in the hospital during the course of treatment. Among those who are dead, APRI index has a median value of 12.58 and Child Pugh score of median 15.Among the dead, had a MELD score of mean of 36.08 with standard deviation of 5.946.

Keywords: correlation, APRI Index, Child Pugh Score, MELD score.

1. Rafael Lozano et al, Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010, Lancet 2012; 380: 2095–128
2. Radan Bruha, Karel Dvorak, Jaromir Petrtyl, Alcoholic liver disease, World J Hepatol 2012 March 27; 4(3): 8 -90.
3. Stefano Bellentani1, Claudio Tiribelli. The spectrum of liver disease in the general population: lesson from the Dionysos study, Journal of Hepatology 35 (2001) 531–537
4. S Bellentani et al, Drinking habits as cofactors of risk for alcohol induced liver damage, Gut 1997; 41: 845–850
5. Jennifer Hatton, Drinking patterns, dependency and life-time drinking history in alcohol-related liver disease, Addiction, 104, 587–592
6. Ying Peng, Xingshun Qi, Xiaozhong Guo. Child–Pugh Versus MELD Score for the Assessment of Prognosis in Liver Cirrhosis, Medicine  Volume 95, Number 8, February 2016
7. Chun-Tao Wai et al. A Simple Noninvasive Index Can Predict Both Significant Fibrosis and Cirrhosis in Patients With Chronic Hepatitis C, HEPATOLOGY, Vol. 38, No. 2, 2003.
8. Christopher M. Moore et al, The MELD Score: Limitations and consequences. WSEAS TRANSACTIONS on BIOLOGY and BIOMEDICINE, Issue 2, Volume 9, April 2012
9. Kasper et al, Harrisons Principals of Internal Medicine, 1995 Table 357-4

Dr Jithin George

Post Graduate, S.S. Institute of Medical Sciences and Research Centre,

Davangere, Karnataka, India