Abstract
Introduction: Diabetes Mellitus is one of the health burden in the world. It is a metabolic syndrome leading to many systemic complication. This present study was aimed to assess association of proteinuria in type 2 diabetes mellitus patients. Total 85 patients with age range of 40 to 90 years were taken randomly, from Kathmandu Medical College and Teaching Hospital, Duwakot.
Objectives: To find out the association of proteinuria in type 2 diabetic patients.
Materials and Methods: This cross-sectional, prospective study was done in 85 patients with age 40-90 years. All known case of type 2 diabetes were taken. The test for proteinuria was done by qualitative method (coagulation method), using reagent 3% sulphosalicylic acid. In this techniques, 1% reagent was mixed with 3% sample of urine. Grading of proteinuria was obtained by the colour and transparency of sample.
Results: The mean age of the patients were 61.74, standard deviation ±11.46 and maximum age was 90 years and minimum was 40 years. In total patients, 17.6% patients had proteinuria. In this study, female patient showed higher (10.70%) incidence of proteinuria than male (7.05%). But there was no significant relation of proteinuria with increased age.
Conclusion: This study showed 17.6% prevalence of proteinuria in type 2 diabetic cases. The incidence of proteinuria was more common in female than male. No significant relation of proteinuria with gender and age.
Keywords: Coagulation method, Proteinuria, 3% sulphosalicylic acid, Type 2 diabetes.
References
- Chivler ER, Hunter J, Boon NA, editors. Davidson’s Principle and Practice of Medicine. 8th Edinburgh: Churchill Livingstone; 1999. p. 472.
- Barret KE, Barman SM, Boitano S, Brooks HL, editors. Ganong’s Review of Medical Phyiology. 23rd New Delhi: Tata McGrawl Hill; 2010. p.333.
- Diet and Exercise Delay Diabetes and Normalize Blood Glucose [online].2002. [Cited 2013 Sept.25]. Available from: http://www.nih.gov/news/pr/feb2002/hhs-06.htm
- American Diabetes Association. Correlation between A1C level and Mean Plasma Glucose Levels on Multiple Testing over 2–3 months. 2006;29:551–80.
- Knudtson MD, Lee KE, Gangnon R, Klein BE. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalm-ology.2008 Nov;115(11):1859-68.
- Klein R, Klein B. Epidemiology of proliferative diabetic retinopathy. Diabetes Care 1992;15:1875-91.
- Proteinuria [online].2007 [Cited 2013 Sept. 25]. Availabe from: http://kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/#1
- Gale EA, Gillespie KM. Diabetes and gender. 2001 Jan;44(1):3-15.
- Rahmanian K, Shojaei M, Sotoodeh A, Jahromi MS. Relation of type 2 diabetes mellitus with gender, education, and marital status in an Iranian urban population. Biochem. Mol. Biol 2013;1(2):1-5.
- Vibert GC, Mackintosh D, Bilous RW, Pickup JC, Keen H. Proteinuria in diabetes mellitus: Role of spontaneous and experimental variation of glycemia. Kidney International 1982;21:714–720.
- Mohan V, Meera R, Premalatha G, Deepa R, Miranda P, Rema Frequency of proteinuria in type 2 diabetes mellitus seen at a diabetes centre in southern India. Postgrad Med J 2000 September; 76(899): 569–73.
- Varghese A, DeepaR, Rema M, Mohan V. Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India. BMJ. Vol 77(908):309.
- Liang H, Kennedy C, Manne S, Hsiang L, Dolin P.BMJ Open Diabetes Research and Care.2014;Vol 3(1):71.
- Aryal M, Jha B.Assessment of proteinuria as a marker of nephropathy in type 2 diabetes mellitus.Nepal Med Coll J.2006 Dec;8(4):250-3.
- William C, David JP, Peter H. Incidence of proteinuria in type 2 diabetes mellitus in the Pima Indians CHARLES L. KUNZELMAN,' Kidney International, Vol. 35 (1989), 681—687.
- Ballard DJ, Humphrey LL, Melton LJ 3rd, Frohnert PP, Chu PC, O'Fallon WM, Palumbo PJ. Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. Diabetes.1988 Apr;37(4):405-12.
Corresponding Author
Dr. Chandra Kala Rai
Kathmandu Medical College and Teaching Hospital, Bhaktapur, Nepal
Contact No. 977-9841380032, Fax No.977-01-6616568, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.