Title: Spectrum of Colorectal Cancers in a Tertiary Care Centre-A Clinico-Pathological Correlation
Authors: Dr P.S.Mulay, Dr Soundararajan Rama, Dr S.A.Deshpande, Dr M.M.Mattawar
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.99
Abstract
Introduction: Large intestine is affected by various types of lesions, both non-neoplastic and neoplastic. Due to vague symptoms, the clinical diagnosis is usually delayed. Colorectal cancer is the third leading cancer worldwide, accounting for approximately 9% of all cancers. A set of laboratory tests including biopsy is essential to arrive at a specific diagnosis for appropriate management.
Aims and Objectives: The aim of this study is to find out the site wise distribution of colorectal tumours and to study the clinical profile and histopathology of various lesions.
Materials and Methods: This two years study was done in Department of Pathology, Dr SCGMC Nanded from 2015-2017 which included biopsies and resected specimens of large intestine and Anal canal. All tissues were fixed in formalin, stained with H&E and special stains like Periodic Acid Schiff (PAS), Reticulin, Zeihl Neelsen (ZN) were done as and when required.
Results: Out of 37 malignant lesions, 13 cases(35.0%) were Well differentiated Adenocarcinomas, 10 cases (27.1%)were Moderately differentiated Adenocarcinomas, 01 case (02.7%) was Poorly differentiated, 05 cases (13.6%) were Mucin secreting Adenocarcinomas and 01 case(02.7%) was Signet ring cell carcinoma. The most common histological grade in the present study was well differentiated Adenocarcinoma.
Conclusion: Adenocarcinomas are the most common malignant lesions of colon in our study. As there is increasing incidence of malignancies early diagnosis by endoscopic biopsies in clinically suspicious patients is recommended for good management.
Keywords: Adenocarcinoma, Colon, Rectum, Histopathology, Malignant lesion.