Abstract
Introduction: Either independently or in association with other factors low vitamin D is one of risk factors in coronary atherosclerosis athough the causal relationship is not yet established.
Aim & Objective: To study the prevalence of vitamin D deficiency in patients with acute myocardial infarction and to study if any association exists between them.
Materials & Methods: Hundred cases of acute myocardial infarction (MI) and hundred healthy controls were included in this study. The study was conducted at SDM hospital Cum Medical Research Institute, Jaipur during November 2015 to October 2016. Biochemical and clinical risk factors assessed for MI .Serum 25 (OH) vitamin D levels measured using radioimmunoassay.
Results: Severe vitamin D deficiency (25(OH) vitamin D less than 10 ng/ml) found in 67% of cases and 48% of controls. Vitamin D deficiency (25(OH) vitamin D 10_<30 ng/ml) found in 24% of cases and 34% of controls. Sufficient vitamin D ( 25(OH) vitamin D >30 ng/ml) found in 9% of cases and 18% of controls. Risk of Myocardial infarction in patients with severe vitamin D deficiency associated with an odds ratio of 2.19 (95% CI 1.1-4.9) (statistically significant p<0.05).
Conclusions: High prevalence of vitamin D deficiency was found among patients of acute Myocardial Infarction and controls. 25 (OH) vitamin D was significantly lower in cases as compared to controls. Even after considering for conventional risk factors for myocardial infarction severe vitamin D deficiency was associated with risk of acute myocardial infarction.
Keywords: Myocardial Infarction, Vitamin D Level, Atherosclerosis.
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Corresponding Author
Vivek Gupta
Registrar, SDM Hospital, Jaipur
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.85
