Title: A Rare Case Report of Progressive Multifocal Leukoencephalopathy in HIV Positive Patient
Authors: Dr Akash Pallem, Dr Sivaprakash Varadan, Dr K Madhavan
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.43
Abstract
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system that is caused by reactivation of the polyomavirus JC (JC virus)1-3 . In most individuals, JC virus remains latent in kidneys and lymphoid organs, but, in the context of profound cellular immunosuppression, JC virus can reactivate, spread to the brain, and induce a lytic infection of oligodendrocytes, which are the CNS myelin-producing cells. since the widespread use of combined ART started ,the incidence of PML in patients with HIV has decreased4,5.so high index of suspicion is needed. We present a case of 45 yr male diagnosed to have pml.
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