Abstract
Background: In general anaesthesia, hypertension and tachycardia caused by endotracheal intubation may lead to cardiac ischemia and arrhythmias. Dexmedetomidine attenuates the hemodynamic response to endotracheal intubation and decreases anaesthetic requirement. The purpose of this study was to evaluate the effect of intravenous dexmedetomidine 1μg/kg given over 10 minutes before induction of anaesthesia, on haemodynamic stress response resulting from laryngoscopy and endotracheal intubation .
Materials and Methods: Seventy patients scheduled for elective surgery were randomized into two groups each having thirty five patients-dexmedetomidine group (Group 1) and control group (Group 2). Heart rate, systolic blood pressure, and diastolic blood pressure were recorded at just before intubation, immediately after intubation, 1, 2, 3, 4, 5 minutes after intubation.
Statistical Analysis: The data was analysed by SPSS 16.0 with independent t-test.
Results: Pretreatment with dexmedetomidine 1 ug/kg attenuated the cardiovascular and catecholamine responses to tracheal intubation.
Conclusions:Intravenous dexmedetomidine significantly attenuates sympathoadrenal response to laryngoscopy and endotracheal intubation, without affecting cardiovascular stability.
Keywords: Dexmedetomidine, endotracheal intubation stress response, α2 adrenergic,laryngoscopy and hemodynamic changes.
MeSH term: Dexmedetomidine Hydrochloride
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Corresponding Author
Dr Rommy Geever T.
Sree Mookambika, Institute of Medical Sciences, Padanilum,
Kulasekharum,, Kanyakumari District,, Tamilnadu, 629161 India
DOI: http://dx.doi.org/10.18535/jmscr/v3i12.33
