Title: Effect of Hibiscus sabdariffa extract orally Administered on Lipid Parameters of Albino Rats
Authors: Ibioku Elekima*, Donatus Onwuli, Uchechukwu Achor Obisike, Constancy Prisca Aleru, Serekara Gideon Christian, Josephine Osiagor
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.73
Abstract
Lipid parameters were investigated in albino rats of different groups after administration of 0.0mg/ml, 25.0mg/ml, 50.0mg/ml, 100.0mg/ml and 200.0mg/ml of aqueous extract of Hibiscus sabdariffa. The results obtained show that total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels of the control group were 112.70±1.84, 103.80±1.22, 26.14±1.71 and 66.35±1.02 respectively. The control results when compared to the study groups of B, C, D and E whose values were 89.75±1.97, 82.26±2.79, 73.65±2.19, 64.39±1.58; 99.73±1.76, 95.44±1.50, 90.26± 1.66, 85.58±1.31; 27.38±1.19, 30.25±2.11, 33.35±1.03, 35.34±1.70, and 42.44±1.32, 32.89±1.15, 22.57±1.39, 11.9±0.53 respectively showed a significant decrease (p≤ 0.05) for cholesterol, triglyceride and LDL-cholesterol. However, HDL-cholesterol showed a significant increase (P≤ 0.05) when compared with the control group. These findings implies that the administration of Hibiscus sabdariffaaqueous extract have protective effects against hyperlipidemia related disorders such as cardiovascular diseases.
Keywords: Hibiscus sabdariffacalyx (leaves);Total Cholesterol; Triglycerides; High Density Lipoprotein; Low Density Lipoprotein.
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