Title: Role of Exchange Transfusion In Dapsone Poisoning
Authors: Dr Nilesh Bastewad, Dr Harshal Bhitkar, Dr Pramod Umarji, Dr Deelip Kadam
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.20
Abstract
Suicidal ingestion of Dapsone can lead to severe methemoglobinemia. Exchange Transfusion decreases Meth-Hb level. We present a young female with suicidal ingestion of Dapsone who responded to Exchange Transfusion.
References
1. Linakis JG, Shannon M, Woolf A, Sax C. Recurrent methemoglobinemia after acute dapsone intoxication in a child. J Emerg Med 1990;8:351-2.
2. Mac Donald RD, McGuigan MA. Acute dapsone intoxication: A pediatric case report. Pediatr sEmerg Care 1997; 13:127-9.
3. Sahoo SK, Tripathy N, Debi BP. Acute fatal DDS poisoning. Lepr India 1979;51:244-8.
4. Price D. Methemoglobinemia. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, editors. Goldfrank'sToxicologic emergencies, 6th ed. Stamford: Appleton & Lange; 1998. P-1507-19.
5. Disanto AR, Wagner JG. Pharmacokinetics of highly ionized drugs. II: Methylene blue- absorption, metabolism and excretion in man and dog after oral absorption. J PharmSci1972;61:1086-90.
6. Ferguson AJ, Lavery GG. Deliberate self poisoning with dapsone: A case report and summary of relevant pharmacology and treatment. Anaesthesia1997;52:359-63.
7. Kumar A, Antony TJ, Kurein KM, Taneja LN, Mohan M, Anand NK. Exchange transfusion of dapsone poisoning. Indian Pediatr1998;25:798-800.
8. Berlin G, Brodin B, Hilden JO, Martensson J. Acute dapsone intoxication: A case treated with continuous infusion of methylene blue, forced diuresis and plasma exchange. J ToxicolClinToxicol1984;22:537-48.