Title: Oral Submucous Fibrosis- A Review on Clinical Presentation, Histology, Epidemiology, Aetiology, Pathogenesis, Malignanat Potential and Management
Authors: Dr Girish Aggarwal, Dr Rajesh Bansal, Dr Vandana Chabbra, Dr Gourav Popli, Dr Sangeet Sethi, Dr Ankita Khatri
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.17
Abstract
Oral submucous fibrosis (OSMF) is a chronic, devastating disease characterised by juxtaepithelial fibrosis of the oral cavity. (1) Oral submucous fibrosis (OSMF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSMF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSMF is a diagnosis based on clinical symptoms and is confirmed by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved (2). We review and discuss all OSMF, including the terminology, presentation, aetiology, and pathogenesis, and provide a brief overview of its conservative and surgical management.
KEYWORDS- Oral Submucous Fibrosis, Epidemiology, Aetiology, Pathogenesis, Clinical Presentation, Management.
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