Pure red cell aplasia (PRCA) is a clinical syndrome defined by the absence of mature erythroid precursors in another wise normocellular bone marrow. PRCA is considered to be an extra articular manifestation of rheumatoid arthritis and is very rare cause of anemia in Rheumatoid Arthritis with only very few cases reported till now. Herein we report a case of 52 year old female with long standing untreated seropositive arthritis who presented to us with severe symptomatic anemia. After proper work up including bone marrow examination, her findings were consistent with pure red cell aplasia.

Key words: Anemia, Pure Red Cell Aplasia, Rheumatoid arthritis 

1.      Charles RJ, Sabo KM, Kidd PG, Abkowitz JL.  The Pathophysiology of Pure Red Cell Aplasia: Implications for Therapy. Blood. 1996 June 1;87:4831-38.

2.      Bandyopadhyay SK, Bandyopodhyay R, Dutta A. Acquired pure red cell aplasia in a patient of Rheumatoid arthritis and autoimmune hypothyroidism. J Indian Rheumatol Assoc 2003;11: 87-8

3.      Malipatil  RA, Patil SY. Drug Induced Chronic Acquired Pure  Red cell Aplasia in Adolescent boy. NJIRM      2011;  Vol. 2(3). July-  September ;2(3):98-100.

4.      Howman R , Kulkarni H.    Antibody-mediated acquired pure red cell aplasia (PRCA) after treatment with darbepoetin. Nephrol Dial Transplant . 2007; 22: 1462–64.

5. Vlachaki E, Diamantidis MD, Klonizakis P, Haralambidou-Vranitsa S, Elizabeth Ioannidou-Papagiannaki, Klonizakis L. Pure Red Cell Aplasia and Lymph proliferative Disorders: An Infrequent Association. The Scientific World Journal. 2012; 2012:1-7. doi:10.1100/2012/475313

Kumar Rajesh

Department of Medicine

B.G.H. DNB Hospital, Bokaro India