Title: A Comparative Study of the Status of Oxidative Stress Markers, Antioxidant Enzymes in Alcoholic Hepatitis Patients
Authors: Sanjay Bhatt, M. Itagappa, R.M.Shinde, Bindu Sati, J. B. Gogoi, Jyoti Batra
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.06
Abstract
Background: The exact pro-oxidant and antioxidant status in alcoholic hepatitis is still not clear.
Material & Methods: The present study was conducted in Department of Biochemistry, RMRI, Bareilly and Santosh medical college & Hospital. 35 alcoholic hepatitis patients were subjected to detailed clinical examination and laboratory investigations and the results were compared with 35 controls. Blood samples were collected for oxidative stress parameters. It was observed that there was a significant increase in activities of SOD, GPX, MDA and Catalase activity in patients with alcoholic hepatitis when compared to controls.
Results: Results of our study depict higher oxygen free radical production, evidenced by elevated levels of MDA and decreased levels of GSH, ascorbic acid, vitamin-E and Catalase activity, supporting the evidence of oxidative stress in alcoholic hepatitis patients. Increased activities of antioxidant enzymes might be a compensatory regulation of body in response to increased oxidative stress. Decreased concentrations of antioxidant vitamins support the hypothesis that alcoholic hepatitis is an important causative factor in pathogenesis of lipid peroxidation.
Conclusion: These data reveal that antioxidant defense mechanisms might be impaired in patients with alcoholic hepatitis. These findings also provide a theoretical basis for development of novel therapeutic strategies, such as antioxidant supplementation.
Key Words:Superoxide dismutase (SOD), glutathione peroxidase, catalase, alcoholic hepatitis.
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