Title: Pancytopenia: The Study of Clinical Profile and Aetiology in Tertiary Care Centre
Authors: Mehrotra M.K, Goel Manish, Sood Tanvi, Saxena Harsh, Varshney Amit
DOI: http://dx.doi.org/10.18535/jmscr/v4i3.24
Abstract
Introduction
Material and Methods: 48 patients who fulfilled the inclusion & exclusion criteria were taken in the study to access the clinical profile and etiology of pancytopenia.
Results: Out of 48 patients, most common cause was megaloblastic (33.3%) followed by aplastic (16.7%) anemia & Kala azar (16.7%). Most common symptom was generalized weakness (70.8%) followed by losss of apetite (62.5%). Most common sign was pallor (100%) followed by hepatomegaly (31.2%).
Conclusion: Pancytopenia can be caused by a number of reversible conditions like megaloblastic anemia, infections such as kala azar, dengue. So while evaluating the cases of pancytopenia, we should 1st rule out the reversible conditions as early as possible so that it help in early management which will reduce the morbidity and mortality in patient.
References
1. Williams DM. Panctopenia, aplastic anemia and pure red cell anemia. In: Richard GL, Bithel TC, John F, John WA and John NL, editors. Wintrobe’s clinical haematology. 10th ed. Philadelphia: Lea and Fabiger; 1998. p 1449-1489.
2. de Gruchy GC. Pancytopenia, aplastic anemia, In: Firkin F, Chesterman C, Penington D and Rush B, editors. de Gruchy’s clinical haematology in medical practice. 5th ed. Berlin, Germany: Blackwell Science; 1989. p119-136.
3. Kumar DB, Raghupathi AR; Clinicohematologic analysis of pancytopenia: Study in a tertiary care centre. Basic and Applied Pathology, 2012; 5: 19– 21.
4. Niazi M, Raziq F. The incidence of underlying pathology in pancytopenia: an experience of 89 cases. J Postgrad Med Inst 2004; 18: 76–9.
5. Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Indian Acad Clin Med 2001; 2: 55–9.
6. Tilak V, Jain R. Pancytopenia: a clinico-hematologic analysis of 77 cases. Indian J Pathol Microbiol 1999; 42: 399–404.
7. Savage DG, Allen RH, Gangaidzo IT et al. Pancytopenia in Zimbabwe. Am J Med Sci 1999; 317: 22–32.
8. Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia: a clinico haematological study of 200 cases. Indian J Pathol Microbiol 2002; 45: 375–9