Title: The Comparative Study of Homocysteine, Folate and Cobalamine Level in Hyperthyroid Women and Normal Healthy Women
Authors: Choudhary Nitu, Kumar Rohitash, Dr Vyas R. K.
DOI: http://dx.doi.org/10.18535/jmscr/v4i3.23
Abstract
Background: Thyroid disorders are among the most common endocrine disorders in India. The prevalence and pattern of the thyroid disorders depends on age, sex, geographical factors, food habits and on iodine intake.(1) A Hospital based case-control study was planned, including 50 patients of clinically proven hyperthyroid disease women patient (Case) and 50 age and sex matched controls attending medicine OPD and microbiology department of S. P. Medical College and Associated Group of Hospitals, Bikaner for study of Homocysteine, Folate and Cobalamine levels.
Method: Plasma Homocysteine, Folate and Cobalamine levels were measured by HPLC (High Performance Liquid Chromatography) Method in clinical Biochemistry laboratory, S. P. Medical College, Bikaner.
Results: A statically significant decreased concentration of plasma homocysteine was recorded in hyperthyroid patients as compared to Controls (p-value 0.0001). The serum vitamin B9 (folic acid) concentration was found to be decreased significantly in hyperthyroid female patients as compared to Controls (p-value 0.0001). A statically significantly increased concentration of serum cobalamine ( Vit B12) was found in hyperthyroid patients as compared to normal control female subject (p-value 0.0001).
Conclusion: Estimation of Serum Homocysteine, Folate and Cobalamine level is simple, reliable, economic and sensitive and it can be used in the proper management of developing new therapeutic strategies in treatment of hyperthyroid women patients.
Keywords: Homocysteine, Folate, Cobalamine, Hyperthyroidism.
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