Title: Assessment of Blood Iron and Manganese on Artesant Welders Exposed to Welding Fumes
Authors: Torka N. Sordum, Ndokiari Boisa
DOI: http://dx.doi.org/10.18535/jmscr/v4i5.47
Abstract
Whole blood iron and manganese levels in artesant welders control subjects were invstigated. Five (5ml) blood samples were collected via venepuncture from thirty (35) welders and twenty five (25) control subjects after their voluntary consent. Samples were digested using standard method. Aliquots of digested samples were assessed for Mn and Fe content with Atomic Absorption Spectrophotometer. The data obtained were expressed as the mean ± Standard Deviation. Independent sample t- test was conducted with the means with SPSS Version 22.0. It was observed that both welders and controls subjects the mean ± S.D were 3.37± 1.34 µg/l and 3.34 ± 1.43 µg/l respectively. Means and standard deviations of blood manganese (Mn-B) levels in welders and controls subjects were 3.37 ± 1.34 µg/l and 3.34 ± 1.43 µg/l respectively. Means and standard deviations blood iron (Fe-B) levels for welders and control subjects were 410 ± 104 µg/dl and 166 ± 37 µg/dl respectively. Significant difference at p < 0.001 was observed when means for test and control subjects were compared. There were no correlations between Mn-B and Fe-B levels of welders with duration of exposure and age. This study has revealed that welders in Elekahia Estate, Community and railway off Trans –Amadi Layout of Port Harcourt have normal Mn-B level with non welders while there Fe-B level is exceptionaly high than non welders. Exposure to iron, may cause iron overload (siderosis) and iron accumulation in liver, heart, and kidney leading to hepatomegaly, myocardial siderosis and metabolic acidosis.
Keywords: Iron; Manganese; Welder; Duration of exposure; Welding fume; Welding electrode.
References
1. Carl, A., Burtis, E. & Ashwood, R. (2001). Tietz fundamentals of clinical chemistry (5th edition) pp. 990-991.
2. Keen, C..L., Ehsunsa, J. L, &Watson, M. H, (2000).. Nutritional aspects Manganese from Experimental Studies. Neuro-toxicology, 20(3), 213-223.
3. Santamaria, A. B. & Sulsky, S. I. (2010). Risk assessment of an essential element manganese. Journal Toxicology Environ-mental Health, 73, 128 – 155
4. Barce, D. G., (1999). Manganese. Journal of Toxicology, 37, 293- 307.
5. Antonini, J. M., Santamaria, A. B., Jenkins, N. T., Albini, E. & Lacchini, R. (2006). Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects neurotoxicology; 27, 304 – 310.
6. Crossgrove, J.R., & Zheng, W., (2004). Review of Manganese Toxicity upon over-exposure, NMR Biomedical Jou, 17, 8- 14
7. Agency for Toxic Substances & Disease Registry (2012). Toxicological Profile for Manganese. Journal Toxicology of Environmental Health, 3 (1), 28 – 55.
8. Ellingsen, D. G., Kon, Stantmov, R., Bast-Pettersen, R., Merkerfera, L., Cheshhan, M. & Thomassen, Y. (2008). A neurobehavioural study of current ano tonner welders expose to manganese. Neurotoxicology, 29, 48 – 59.
9. Chang, Y., Lee. J. J., Seo, J. H., Song, H. J., Kim, J. H. & Baes, J. (2010). Altered working memory process in the mangane-se exposed brain. Neurology,53(4),1279 – 1285.
10. Blaurock-Busch, E. (1999). Mineral and trace element analysis. Laboratory and Clinical Application Journal.5(1), 45 – 76.
11. Annual Report of the American Associ-ation of Poison Control Centers (AAPCC) National poison data system report.
12. Oruambo, I. F., Brown, H. & Okeh, C. (2013). Correlation between exposure to toxic heavy metals in fish, sediment and drinking water, and high incidence of parasitatals enlargement in two states of the Niger Delta, Nigeria. Biochemistry and Biotechnology Research, 2(1), 1 – 5.
13. Levy, B. S. & Nassetta, W. J. (2003). Neurologic effects of manganese in human. A review: International Journal Occupation Environmental Health, 9(2), 153 – 163.
14. Ling, L., Long-Lian, E. Zhang, S., Jane, L., Wennis, G., Wannian, L. & Wei, Z. (2005). Alteration of serum concentration of Manganese, Iron, Ferrtin and trans-ferrin. Neurotixicology, 26(2), 257- 265
15. Li, G. J., Zhang, L., Lu, L., Wu, P. & Zheny, W. (2004). Occupational exposure to welding fume among welders alterations of manganese, iron, zinc, copper, and lead in body fluid and the oxidative stress status. Journal of Occupational Environmental Medicine,46, 241 – 248.
16. Rosemeria, M., Bowler, Harry, A., Roels, S. N., Managa, D., Emily, D., Robert, P., William, K., Russell, P., Bouler, D. M., Manyse, B., Donald, S., Roberto, G. & Richard, L. D. (2007). Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders. Occupational Environmental Medicine, 64, 167 – 177.
17. Smargiass, I. A. & Mutti, B. (2000). Assessment of exposure to manganese in welding operation during the assembly of heavy excavation machinery accessories. Application Occupational Environment, 15, 746 – 750.
18. Kim, Y. and Lee, B. K. (2012). Iron deficiency instead blood manganese level in the Korean general population according to Knhanes. Neurotoxicology, 33(3), 401 – 405.
19. Davis, C. D., Wolf, T. J. & Greoger, J. L. (1992). Varying levels of manganese and iron affect absorption and gut endogenous losses of manganese by rats. Journal of Nutrition, 120(6), 1300 – 1308.
20. Zheng, W. (2001). Neurotoxicology of the brain system, new implication. Journal Toxicology Clinical Toxicology, 39, 711 – 719.