Background: Overall incidence of Gallbladder(GB) malignancy is rare but it is the most common primary hepatobiliary carcinoma. Its incidence is highest in India and median survival is less than 6 months. Different chemotherapy regimens have been tried. These days Gemcitabine with cisplatin is the most preferred therapeutic approach but still less number of patients are achieving the 1 year survival. But studies on oxaliplatin and fluropyrimidine combination shows appreciative results in term of overall survival .These evidences led us for current prospective study to compare these two regimens in locally advanced carcinoma GB. 

Aim: The primary objective was to compare the overall survival while secondary objectives were to assesss the response rate & toxicity.

Method and Material: This single institution study included 50 cytopathologicaly proven advanced stage Carcinoma GB patients and randomizd into ARM A (gemcitabne and cisplatin) and ARM B( oxaliplatin and 5FU). 4

Result: OS for arm A was 5± 0.504(95%CI, 4.012-5.988) months and for arm B was 5.5 ±.542 (95%CI , 44.37-65.63)months. Most common side effects was nausea/vomiting and Anemia for arm A and arm B respectively. 

Conclusion: oxaliplatin and 5-FU regimen can be considered as first line chemotherapy or second line chemotherapy in patients with advanced stage carcinoma GB. To confirm these results , study on larger no. of patients population with advanced carcinoma GB needs to be undertaken with randomization. 
Keywords: Carcinoma Gall Bladder, Gemcitabine , Cisplatin,Oxaliplatin,5-FU.

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Roopali

Department of Radiation Oncology

King George's Medical University, Lucknow U.P. India