Title: A Study on the Association of Hypertension and Hyperparathyroidism in Diabetic Chronic Kidney Disease Patients
Authors: Piyush Saxena, Raju Kumar, Arvind Gupta
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.36
Abstract
Introduction: Prevalence of hypertension is high in diabetic CKD patients. Hypertension is one of the important risk factors for cardiovascular diseases in uremic patients. cardiovascular diseases are the most important etiologies causing mortality and morbidity in these patients.. Left ventricular hypertrophy is also found in many CKD patients; its contributing factor other then hypertension is unsolved issue. Hyperparathyroidism and vitamin D can be the others.
Aims & Objectives: To study the association of Hypertension and Hyperparathyroidism in patients of diabetic CKD. To study the association of Hypertension and vitamin D levels in patients of diabetic CKD. To study the association of Hyperparathyroidism and vitamin D with Left ventricular hypertrophy in patients of diabetic CKD.
Results: Out of 90 cases ;The mean serum PTH was 202.37±66.4 pg/mL in prehypertensive group 207±82.7 pg/mL in the patients with stage I Hypertension and 350.5±140.5 pg/mL in the patients with Stage II Hypertension showing significant correlation (P =0.000 ) between Hypertension and iPTH levels.When cases were stratified according to iPTH quartiles (<150,150-299 ,300-449 ,>450 pg/ml) Systolic Blood Pressure(P =0.0000),and Diastolic Blood Pressure (P =0.000) were found to be significantly correlating with iPTH. Also there is significant relation (P=0.027) between vitamin D levels and development of left ventricular hypertrophy. However no correlation between left ventricular Hypertrophy and i PTH levels was found (P=0.706).
Conclusions: In this study, we could show a significant relationship between hypertension severity and serum i PTH level in diabetic CKD patients. While no association between Hypertension and vitamin D deficiency was found .Left ventricular hypertrophy was significantly related with serum vitamin D levels. However no correlation between left ventricular hypertrophy and i PTH levels was found.
Keywords: CKD, Hypertension, LVH, Hyperparatyhyroidism, Diabetes, Vitamin D
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