Title: Metaplastic Carcinoma of Breast with Chondrosarcomatous Differentiation-A Rare Case Report
Authors: Dr Neha Kurmi, Dr Lalit Mohan Patel, Dr Naveen Kumar Verma, Dr Varsha Pandey, Dr Rajni Verma
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.60
Metaplastic carcinomas of breast are rare neoplasms. They are highly heterogenous groups of tumors that are characterised by an admixture of adenocarcinoma with dominant areas of spindle cell, squamous, and/or mesenchymal differentiation[1,2]. Other than a lower rate of lymph node metastases, MBC (metaplastic breast carcinoma) display poorer prognostic features relative to IDC. Due to its relative rarity and heterogenous histologic presentation, the pathologic diagnosis of MBC is difficult. We report a case of metaplastic breast carcinoma in whom fine needle aspiration cytology was performed with later histological confirmation. 1. Kim et al. Metaplastic carcinoma with extensive chondroid differentiation in the breast. Yonsei Med J. 2006;47(2):259-263. 2. Tavassoli FA. Pathology of the Breast. 2nd ed. Stamford (CT): Appleton & Lange; 1999. pp. 481-504. 3. Schwartz et al. Experimental Haematology & Oncology 2013,2:31, DOI:10.1186/2162-3619-2-31. 4. Venkatachala et al. Metaplastic breast carcinoma with extensive chondrosarco-matous differentiation. Indian J Pathol Microbiol. 2014;57:146-7. 5. Chao TC et al.Metaplastic carcinoma of the breast.J Surg Oncol.1999;71:220-225 6. Dhruv R. Shah et al. Treatment options for metaplastic breast cancer. ISRN.2012, Article ID 706162,DOI:10.5402/2012/706162. 7. Fenyvesi A. A case of carcinoma of the breast with metaplasia to chondrosarcoma: light microscopic and immunohistochemi-cal features. Arch of Oncol 2003;11:273-6. 8. Gupta Y, Arora S et al. Metaplastic Carcinoma of Breast. JK Science.2009; 11(3):144-145. 9. Yamaguchi R, Horii R, Maeda I, Suga S, Makita M, Iwase T, et al. Clinicopathologic study of 53 metaplastic breast carcinomas: Their elements and prognostic implications. Hum Pathol 2010;41:679-85Abstract
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