Title: Association of Non-Alcoholic Fatty Liver Disease and Hepatic Enzyme Levels – A Case Control Study
Authors: Punya Chandan, Vikram Gowda N R, Remony George
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.59
Non alcoholic fatty liver disease (NAFLD) is considered as the hepatic representation of metabolic syndrome. It is one of the leading cause of asymptomatic elevation of serum transaminases in the western world. Our study aimed at recognizing the association between NAFLD and hepatic enzymes in our population. At the end of our study we were able to demonstrate significant elevation of AST (P=0.046) and ALT (P=0.021). So we conclude that although previously thought as a condition of unknown significance NAFLD is associated with an asymptomatic elevation of hepatic transaminases. Keywords- non alcoholic fatty liver disease, serum tranaminases, AST, ALT. 1. “Third Report of the National Cholesterol Education Pro- gram (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report,” Circulation, vol. 106, no. 25, pp. 3143–3421, 2002. 2. A I.Shulman and D. J. Mangelsdorf, “Retinoid X receptor heterodimers in the metabolic syndrome,” The New England Journal of Medicine, vol. 353, no. 6, pp. 604–615, 2005. 3. Amarapurkar et al. Prevalence of non-alcoholic fatty liver disease: A population based study Ann. hepatol 2007; 6(3): July – September 161 – 163. 4. Farrell GC, Larter CZ. Nonalcoholic Fatty Liver Disease: from Steatosis to cirrhosis. Hepatology 2006; 43: S00-S112. 5. Hashimoto E, Yatsuji S, Tobari M, Taniai M, Torii N, Tokushige K, Shiratori K. hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. J Gastroenterol. 2009;44 Suppl 19:89-95. 6. Smedile A, Bugianesi E. Steatosis and hepatocellular carcinoma risk. Eur Rev Med Pharmacol Sci. 2005;9:291-3. 7. Sanyal AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 2002;123:1705–1725. 8. D. M. Torres and S. A. Harrison, “Diagnosis and therapy of nonalcoholic steatohepatitis,” Gastroenterology, vol. 134, no. 6, pp. 1682–1698, 2008 29, 32Abstract
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