Title: Role of Antioxidants and Antioxidant Enzymes in Asthmatic Children
Authors: Neela A.Vaidya, P.M.Bulakh
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.30
Abstract
In children, respiratory system is not completely developed .Continuous exposure to environmental factors, pollutants and various infectious agents such as viruses, bacteria etc, makes the system vulnerable to inflammatory reactions. Epithelial cells, resident macrophages, endothelial cells and recruited inflammatory cells, generate ROS in response to increased levels of secretory toxins. ROS produced by phagocytes at sites of inflammation and increased oxidative stress are a major cause of cell and tissue damage associated with various acute and chronic inflammatory lung diseases.
Clinically diagnosed and established seventy five cases of Asthma with sixty normal healthy controls in paediatric group were included in this study. Efficacy of the antioxidant system was evaluated by measuring specific activities of antioxidant enzymes PON1, SOD, CAT, GPx, GRx and measuring antioxidants vitamin E and ascorbic acid .Present study shows significant decrease in antioxidant enzymes SOD, CAT, PON-1 (p<0.001) and antioxidants with increased levels of MDA (p<0.001) with moderate changes in GPx and GRx levels in asthmatic children as compared to control.
Keywords- ROS, antioxidants, paraoxonase1, asthma.
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