Title: Non-Pharmacological Treatment for Non Alcoholic Fatty Liver Disease- A Review
Authors: Tamizh Paavai Tha,T.A.Naufal Rizwan
DOI: http://dx.doi.org/10.18535/jmscr/v4i8.61
Abstract
Non alcoholic fatty liver disease is the most common liver disease worldwide. It is defined as an accumulation of lipids in the hepatocytes exceeding 5% of the liver weight in the absence of excessive ethanol intake and without other causes of liver disease. Although the specific etiology is unknown, obesity related inflammation status, insulin resistance and also genetic, dietary and lifestyle changes are found to play a key role. The prevalence of NAFLD in the Asian countries is found to be between 15%-20%.
KEY WORDS: Non alcoholic, fatty liver, non pharmacological, diet.
References
1. Deepak NA, Estsuko H, Laurentius AL, José DS, Pei-JC, Khean-LG, et al. How common is non-alcoholic fatty liver disease in the Asia–Paci c region and are there local differences?. J Gastroenterol Hepatol 2007;22:788–93.
2. György B, Elizabeth MB, Stephen HC. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 2012;56:1384–91.
3. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non- alcoholic fatty liver disease. Dig Dis. 2010;28(1):155–161.
4. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005;42(1):44–52.
5. ames WP. The epidemiology of obesity: the size of the problem. J Intern Med. 2008;263(4):336–352.
6. Nimer A. Nutritional recommendations for patients with non-alcoholic fatty liver diseases. World J Gastroenterol 2011;17: 3375-6.
7. Bath G, Baba CS, Pandey A, Kumari N, Choudhuri G. Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease. World J Hepatol 2012;4:209-17.
8. Larson-Meyer DE, Newcomer BR, Heilbronn LK, et al; Pennington CALERIE Team. Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. Obesity (Silver Spring). 2008;16 (6):1355–1362.
9. Ryan MC, Abbasi F, Lamendola C, Carter S, McLaughlin TL. Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care. 2007;30(5): 1075–1080.
10. de Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Conde R. Effect of two different hypocaloric diets in transaminases and insulin resis- tance in nonalcoholic fatty liver disease and obese patients. Nutr Hosp. 2010;25(5):730–735.
11. Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB; NASH CRN Research Group. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol. 2011;106(3):460–468; quiz 469.
12. Bae JC, Suh S, Park SE, et al. Regular exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in indi- viduals with NAFLD independent of obesity in Korean adults. PLoS One. 2012;7(10):e46819.
13. Shira ZS, Vlad R, Ran O. Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence. World J Gastroenterol 2011;17:3377-89.
14. Chalasani N, Younossi Z, Joel EL, Anna MD, Elizabeth MB, Kenneth C, et al. The diagnosis and management of non- alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012;55:2005-23.
15. Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. NEJM 2004;351:2683–93.
16. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. NEJM 2007;357: 741–52.
17. Mathurin P, Hollebecque A, Arnalsteen L, et al. Prospective study of the long-term effects of bariatric surgery
18. Chavez-Tapia NC, Tellez-Avila FI, Barrientos-Gutierrez T, et al. Bariatric surgery for non-alcoholic steatohepatitis in obese patients. Cochrane Database System Rev 2010:CD007340.
19. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380:219–229.