Title: The Prevalence of Anti-Thyroid Peroxidase Antibodies among Patients with Thyroid Swelling with Reference to FNAC and Thyroid Hormones
Authors: Hanushraj. R, Sudharsan. S, Balasubramanian.S
DOI: http://dx.doi.org/10.18535/jmscr/v4i8.56
Abstract
Objective: The aim of the present study was to define the prevalence of anti-thyroid peroxidase antibodies among patients presenting with thyroid swelling and to correlate with their thyroid hormone status (free T3, free T4 and TSH) and FNAC.
Design: Cross-sectional study.
Materials and methods: 30 persons with age above 13 years who presented with complaints of thyroid swelling to our outpatient department were included in our study. Tpo- Ab, free T3, free T4 and TSH were measured and FNAC of the thyroid gland was performed.
Results: The prevalence of anti-TPO-Ab was 53.33% with a female to male ratio of 2.2:1. FNAC of our study population with raised anti-TPO-Ab titer showed 16.66% had colloid goiter, 26.67% had Hashimotos’s thyroiditis, 3.33% had Grave’s disease and 3.33% had multi nodular goitre. Of the total study population 40% were in euthyroid state, 26.67% were in hypothyroid state, 23.33% were in hyperthyroid state and 10% were in subclinical hypothyroid state.
Conclusion: The prevalence of anti-TPO-Ab is higher in patients with thyroid swelling, suggesting thyroid autoimmunity as a risk factor for thyroid swelling. Most of the patients were in euthyroid state. Colloid goiter was the most common FNAC finding
References
1. Shlomo Melmed (2011).“Williams Text Book Of Endocrinology” 13th Edition. Philadelphia, Elsevier.
2. Kenneth MF, Strieder T, Wiersinga WM (2004). The environment and autoimmune thyroid diseases. Eur J Endocrinol; 150(5):605-18.
3. Ghaib H, Goeliner JR. Fine neelde aspiration biopsy of the thyroid: An appraisal. Ann Intern Med 1993; 118: 282-9. PMid:8420446.
4. Nelson JC, Wilcox RB. Analytical performance of free and total thyroxine assay, Clin Chem 1996; 42: 146-154. PMid:8565218.
5. Bravemann LE. Evaluation of thyroid status in patients with thyrotoxocosis, Clin Chem 1996; 42: 174-181. PMid:8565222.
6. Beever K, Bradbury J, Philips D, et al. Highly sensitive assays of auto antibodies to thyroglobulin and to thyroid peroxidase. Clin Chem 1989; 35: 1949-54. PMid:2776323.
7. Kabelitz M, Liesenkotter KP, Stach B, et al. The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area, European Journal of Endocrinology (2003); 148 301-307. www .eje-online.org/content/148/3/301.full.pdf
8. Tamai H, Uno H, Hirota Y. (2005). Immunogenetics of Hashimoto’s and Grave’s diseases. J. Clin. Endocrinology. Metab. 60: 62-65.
9. Chandrakant S. Pandav, Kapil Yadav, et al (2013). Iodine deficiency disorders (IDD) control in India. Indian J Med Res 138, September 2013, pp 418-433. http://i-cmr.nic.in/ijmr/2013/september/0922.pdf
10. Sivaranjani H, Anna C. Das, Govindaiah H. K. Correlation between anti tpo antibodies and fnac in the diagnosis of hypothyroidism: an observational study. Journal of Evolution of Medical and Dental Sciences. 2015;4(65)11362-11366. http://www.jemds.com/data_pdf/1_sivaranjini%20%20%20kumGU.pdf