Title: A Clinical Study Analyze Serum Uric Acid as Risk Factor for Gestational Diabetes Mellitus
Authors: Dr Manisha Chauhan, Dr Saurabh Tomar
DOI: http://dx.doi.org/10.18535/jmscr/v4i10.18
Abstract
Introduction: To analyze the relationship between risk of development of gestational diabetes mellitus (GDM) and first trimester uric acid levels.
Method: After obtaining their demographic data and clinical assessment blood sample for serum uric acid was taken. Women were subsequently followed till term. A total of 300 pregnant women up to 14 weeks of pregnancy were enrolled in this study. All women were subjected to blood sugar screening one hour after 50 gm glucose and glucose tolerance test if screening was < 200mg/dl. GDM was diagnosed by 3 hours glucose tolerance test using Carpenter and Coustan criteria or by one hour screening value > 200 mg /dl.
Results: GDM complicated 2.66% (8/300) of the pregnancies. All the women with serum uric acid > 5 mg/dl (n=6) had deranged blood sugar screening and out of this 5 developed GDM.
Conclusion: First trimester uric acid level may be used as predictor for development of GDM. The study demonstrates a striking association between first trimester uric acid and risk of developing GDM.
Keywords: Uric Acid, Gestational Diabetes Mellitus, Insulin Resistance, Glucose Tolerance Test.
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