Title: A Comparative Study of Inj. Labetalol & Oral Nifedipine in Severe Hypertension in Pregnancy
Authors: Dr Rinkesh Meena, Dr Dharmraj Meena
DOI: https://dx.doi.org/10.18535/jmscr/v4i11.20
Abstract
PIH is a form of high blood pressure in pregnancy. PIH is also called toxemia or preeclampsia. It occurs most often in young women with a first pregnancy. The proposed study was clinical trial of comparison of oral administration of tab. Nifedipine and inj labetalol in case of severe PIH.
Criteria for inclusion in the study were women with blood pressure more than 160/110mm hg.
In nifedipine group 76% patients had a DBP in the range of 110-120mmHg, of these 32% responded favourably but in remaining cases other drugs was added.
Similarly in Labetalol group 72% had DBP in the range of 110-120 mmHg, of which 60% responded to labetalol.
It appears that inj Labetalol is more effective in lowering the diastolic BP in severe PIH as compared to Nifedipine. Further fewer patients needed other anti hypertensive drug in Labetalol group.
Labetalol group had favorable parameters in all aspects. However larger studies are required to establish the superiority of inj Labetalol in PIH.
KEYWORDS:- DBP (Diastolic Blood Pressure), SBP (Systolic Blood Pressure)
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