Title: A Study of Clinicomorphological Profile of Ovarian Tumors in Western India
Authors: Dr Shaheen H. Kanpurwala, Dr Shantanu M. Chavan, Dr Sugam Agrawal
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.120
Abstract
Background: Ovarian tumors are one of the common tumors of female genital tract. The clinical and morphological features of these tumors are variable and also vary with geographic region.
Aim: The aim of study is collection and analysis of data of various clinicomorphological features of ovarian tumors in light of various studies conducted in variable geographic regions.
Results: Age group with peak incidence was 21-40 years. Abdominal pain was the most common symptom (68.8%). Tumors were bilateral in 12.7% patients. Malignant and borderline tumors had a larger mean diameter (>10 cm) as compared to benign tumors (<10cm). Grossly tumors were most commonly cystic (63.7%). Benign tumors were most common (57.32%) followed by malignant (35.66%) and borderline tumors (7%). Serous cystadenoma (35.88%), Borderline mucinous (63.6%) and Serous cystadenocarcinoma (46.4%) were the commonest tumors in benign, borderline and malignant categories respectively. Among histopathological types Surface epithelial tumors (70.07%) were the commonest followed by Germ cell tumors (22.29%), Sex cord stromal tumors (5.09%) and metastatic tumors (2.55%).
Conclusion: In our study, conducted in Western India, clinically lower abdominal pain was the most common symptom in contrast to Western countries wherein abdominal distension was most common. Benign tumors were most common but the incidence of borderline and malignant tumors were proportionately higher when compared to Western nations. Surface epithelial tumors were most common in both benign and malignant categories. Serous cystadenomas, Mucinous borderline and Serous cystadenocarcinoma were the most common tumors in benign, borderline and malignant categories respectively. These findings are important geographical variations since different tumors have been reported to be the commonest in benign, borderline and malignant categories in studies conducted in different geographic areas.
KEYWORDS – Ovarian tumor, incidence, histopathology, Western India.
References
1. Hennessy BT, Suh GK, Markman M. Ovarian Cancer. In: Kantarjian HM, Wolff RA, Koller CA, editors. The MD Anderson Manual of Medical Oncology.
2. Mc Cluggage WG. My approach to and thoughts on the typing of ovarian carcinomas. J Clin Pathol. 2008;61:152–63.
3. Kayastha S. Study of ovarian tumors in Nepal Medical College Teaching Hospital. Nepal Med Coll J. 2009;11:200-2.
4. Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res. 2015;6:11.
5. Bankhead CR, Collin SC, Stokes- Lampard H. Identifying symptoms of ovarian cancer: a qualitative and quantitative study. Brit J Obstet Gynaecol 2008; 115: 1008 -14.
6. Goff B, Mandel L, Melancon CH et al. Frequency of symptoms of ovarian cancer in women presenting to primary care clinics. J Amer Med Assoc 2004; 291: 2705-12.
7. Olson SH, Migone L, Nakraseive C et al. Symptoms of ovartian cancer. Obstet Gynaecol 2001; 90: 75-82.
8. Vine MF, Callingaert B, Berchuk A. Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls. Gynecol Oncol 2003; 90: 75-82.
9. Kant R, Rather S, Rashid S. Clinical and histopathological profile of patients with ovarian cyst presenting in a tertiary care hospital of Kashmir, India. Int J of Reproduction, Contraception, Obstet and Gynaecol 2016; 5(8):2696-270.
10. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: A study of 282 cases. J Indian Med Assoc 2002;100:420, 423-24, 427.
11. Kos M, Nikic J, Lenicek T. Ovarian teratoma in routine biopsy material during a five year period. Acta Clin Croat 2016; 55:265-70
12. Sharma I, Chaliha T. Histopathological Patterns of Germ cell tumors of ovary in a tertiary level hospital. Int J of Pharmaceutical Science Invention 2014; 3(10): 14-24.
13. Hashmi A, Bhagwani A, Edhi M et al. Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective 2016; 9:205.
14. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc 2000;50:416-9.
15. Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Indian J Pathol Microbiol 2007;50:525-7.
16. Scully RE, Young RH, Clement PB. Atlas of Tumour Pathology.Tumours of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. 3rd series, Fascicle 23, Washington DC. Armed Force Institute of Pathology, 1999; 1-168.
17. Shah S, Hishikar VA. Incidence and management of ovarian tumours. Bombay Hospital J 2008; 50:30-3.
18. Thanikasalam K, Ho CM, Adeed N, Shahidan MN, Azizah WK. Pattern of ovarian tumours among Malaysian women at general hospital, Kuala Lumpur. Med J Malaysia 1992;47:139-46.
19. Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumors -- a study on fi ve years samples. Nepal Med Coll J 2010;12:221-3.
20. Yasmin S, Yasmin A, Asif M. Clinicohistological pattern of ovarian tumours in Peshawar region. J Ayub Med Coll Abbottabad 2008;20:11-3.
21. Koonings PP, Campbell K, Mishell DR Jr, Grimes DA. Relative frequency of primary ovarian neoplasms: a10 year review. Obstet Gynaecol 1989; 74: 921-26.
22. Powari M, Dey P, Gupta SK, Saha S. Metastatic tumors of the ovary: a clinicopathological study. Indian J Pathol Microbiol. 2003;46:412-5.
23. Pudasaini S, Lakhey M, Hirachand S, Akhter J, Thapa B: A study of ovarian cyst in a tertiary hospital of Kathmandu valley. Nepal Med Coll J. 2011;13(1):39-41.