Title: Lack of the BRAFV600E Mutation in Oral Squamous Cell Carcinoma
Authors: Samata Gadde, Sudhakar Poda, Suryanarayana Veeravilli, Lakshmi Addala
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.99
Abstract
The aim of this study was to estimate the frequency of BRAF (V600E) mutation in oral squamous cell carcinoma (OSCC) in the south Indian population. In the present study we analyzed the V600E BRAF gene mutation in 100 cases with oral squamous cell carcinoma (OSCC), using a PCR-DHPLC method. Our analyses illustrated that no V600E BRAF gene mutation was detected among the 100 selected patients. Our study is the first one in which the frequency of BRAF (V600E) mutation in oral squamous cell carcinoma (OSCC) was not reported in the south Indian population. This suggests that BRAF V600E mutations may not be playing a role in these OSCC patients.
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