Title: To Study the Role of 48 Hrs Continuous Intravenous Insulin Infusion in Patients of Diabetic Neuropathy
Author: Dr Dhanveer Singh, Dr Shweta Sharma, Dr Anuradha
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.42
Introduction: Diabetic neuropathy is a very common clinical presentation bringing a diabetic pt. to O.P.D. Many studies have shown that use of insulin helps in improvement of symptoms of such patients. Material & Method: In this study 25 patients of diabetic neuropathy were given I/V insulin infusion for 48 hrs. Results: In this study statistically significant improvement was seen in symptoms of paraesthesia (P< 0.05) Hypoaesthesia (p< 0.05) cramps pain (p<0.05) however symp. of vibration sense loss, position sense loss & diminished reflexes didn’t show significant improvement and similarly autonomic symptoms were also not improved. Discussion: This study suggests that insulin has neurotrophic effect on nerves. 1. Akashi, Paula MH, et al. "The effect of diabetic neuropathy and previous foot ulceration in EMG and ground reaction forces during gait." Clinical Biomechanics 23.5 (2008): 584-592. 2. Benbow, S. J., L. Cossins, and I. A. MacFarlane. "Painful diabetic neurop-athy." Diabetic medicine 16.8 (1999): 632-644 3. Cameron, N. E., et al. "Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy." Diabetologia 44.11 (2001): 1973-1988. 4. Callaghan, Brian C., et al. "Diabetic neuropathy: clinical manifestations and current treatments." The Lancet Neurology 11.6 (2012): 521-534. 5. Duby, Jeremiah John, et al. "Diabetic neuropathy: an intensive review." American Journal of Health-System Pharmacy 61.2 (2004): 160-173. 6. Gupta, Arun K., et al. "Fortyeight hour continuous intravenous insulin infusion in patients of diabetic neuropathy." DIABETES. Vol. 57. 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA: AMER DIABETES ASSOC, 2008. 7. Harrison’s principles of internal medicine vol 2,19th edition(2015), p.2422 -2427 8. Kimura, Jun, Thoru Yamada, and Nelson P. Stevland. "Distal slowing of motor nerve conduction velocity in diabetic polyneuropathy." Journal of the neurolog-ical sciences 42.2 (1979): 291-302. 9. LeRoith, Derek, Simeon I. Taylor, and Jerrold M. Olefsky, eds. Diabetes mellitus: a fundamental and clinical text. Lippincott Williams & Wilkins, 2004. 10. Samanta, A., and A. C. Burden. "Rapid improvement in pain of diabetic neurop-athy. Using an open‐loop intravenous insulin infusion system." Practical Diabetes International 2.2 (1985): 22-23. Dr Shweta Sharma Assistant Professor Medicine, LLRM Medical College MeerutAbstract
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