Title: A rare case of Sclerosing stromal tumour with ascites and raised CA 125 mimicking primary ovarian malignancy
Authors: Dr Shahina P.K, Dr Resmi Rajeev, Dr Shameem K. Ummer Ali
DOI: https://dx.doi.org/10.18535/jmscr/v14i02.02
Abstract
Sclerosing stromal tumour is a rare benign sex cord stromal tumour of ovary. A 16 year old female presented with menorrhagia & fever. MRI showed large welldefined heterogenous mass lesion of size 9x11x12cm in the lower abdomen and pelvic cavity. There was mild ascites and serum CA 125 levels were elevated which mimicked the possibility of primary ovarian malignancy . Staging laparotomy was done. Macroscopic examination showed an encapsulated solid mass. Cut section showed grey white solid mass with glistening areas. Histopathological examination showed a neoplasm composed of alternating cellular and hypocellular areas and thin branching hemangiopericytoma like vessels. Immunohistochemical analysis showed positive results for Vimentin, SMA & calretinin. Inhibin, CK, CD 34 & Bcl2 were negative in tumour cells. A diagnosis of Sclerosing stromal tumours was given. About 8% ovarian tumours are sex cord stromal tumours and of these sclerosing stromal tumour compromises less than 5 %. Around 208 cases of SSTs are described in literature till now.(1)
References
- Khanna M, Khanna A, Manjari M. Sclerosing stromal tumor of ovary: a case report. Case reports in pathology. 2012 Oct 12;2012.
- Saha S, Robertson M. Meigs' and Pseudo‐Meigs' syndrome. Australasian journal of ultrasound in medicine. 2012 Feb;15(1):29-31.
- Chandanwale SS, Pal SS, Kumar HB, Sammi AB. Serous cystadenoma and fibrothecoma: a rare combination in collision tumor of ovary with pseudo-Meigs syndrome. Journal of Pathology and Translational Medicine. 2015 Mar 12;49(2):163-6.
- Yazdani S, Alijanpoor A, Sharbatdaran M, Bouzari Z, Abedisamakoosh M, Lakaieandi F, Mohammadpour M. Meigs' syndrome with elevated serum CA125 in a case of ovarian fibroma/thecoma. Caspian journal of internal medicine. 2014;5(1):43
- Bairwa S, Satarkar RN, Kalhan S, Garg S, Sangwaiya A, Singh P. Sclerosing stromal tumor: a rare ovarian neoplasm. Iranian Journal of Pathology. 2017;12(4):402
- LA A. Sclerosing stromal tumor in anaccessory ovary. Gynecol Oncol. 2001;81:318-9
- Young R. WHO classification of tumours of female reproductive organs. Monodermal teratomas and somatic-type tumours arising from a dermoid cyst. 2014:63-
- Liou JH, Su TC, Hsu JC. Meigs’ syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor. Taiwanese Journal of Obstetrics and Gynecology. 2011 Jun 1;50(2):196-200
- Grzybowski J, Piętak P, Merkisz K, Nemeczek S, Marciniak A, Walczak K, Jaskuła K, Orłowski W, Zdun S, Grzywna N, Walczak P. Ovarian sclerosing stromal tumor-benign neoplasm of the young. A case study with literature review. Journal of Education, Health and Sport. 2023 Jan 2;13(2):209-16
- Tanaka YO, Nishida M, Yamaguchi M, Kohno K, Saida Y, Itai Y. MRI of Gynaecological Solid Masses: Pictorial Review. Clinical radiology. 2000 Dec 1;55(12):899-911.
- Akbulut M, Colakoglu N, Soysal ME, Duzcan SE. Sclerosing stromal tumor of the ovary: report of a case and review of the literature. Aegean Pathol J. 2004;1:84-9.
