This is, to our knowledge, the first-in-field case series describing the use of nebulized exosomes for different neurological disorders. Chronic neurological disorders often present overlapping mechanisms of neuro-inflammation, oxidative stress, and impaired cellular repair, and are frequently resistant to standard therapies, highlighting the need for innovative, regenerative treatment strategies. Nebulized exosome therapy is an emerging approach for treating neurological and neuro-degenerative disorders. Exosomes are nano-sized vesicles that facilitate intercellular communication and carry bioactive molecules, including neurotrophic factors that may aid in recovery from neurological disorders by promoting regeneration of brain cells and tissue. Objective: To evaluate the clinical effects of nebulized Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs) derived exosomes in treatment of neurological disorders.

Methods: This case series included eight patients, each diagnosed with a single distinct neurological condition: Parkinson’s disease / fibromyalgia / post-stroke / chronic dizziness / dementia / Friedreich’s ataxia / post-covid / repeated extra-dural haemorrhage. All Patients were treated with nebulized UC-MSCs derived exosomes, number of treatments ranged from 1 to 3 treatments per patient, and the interval between treatments was 4 weeks. Patients’ reports were obtained, and subjective clinical assessment and examination were performed for each patient before the treatment, two weeks after each treatment, then six months after the first treatment.

Results: Following nebulized exosome therapy, all patients reported and demonstrated clinical improvement in both symptoms and neurological signs, except for the patient with pre-existing dementia.

Conclusion: UC-MSCs derived exosomes are emerging as a promising tool in regenerative medicine, and they represent a promising frontier in treatment of neuro-degenerative diseases with a significant potential promising therapeutic effect in different neurological disorders.           

Keywords: Exosomes, extracellular vesicles, extra-cellular cargo, neuro-inflammatory diseases, intercellular communication, drug delivery, biomarkers, cancer, neuro-degenerative diseases, biogenesis, post-stroke, fibromyalgia, parkinson’s disease, dizziness, extra-dural haemorrhage, dementia, Friedreich’s ataxia, post-covid, neurological disorders.

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Dr. Dina SOLIMAN

Section Chief of the American Academy / Association of Orthopedic Medicine in Europe and Africa