Abstract
Anti-IgLON5 antibody disease is a rare neurological disorder characterized by a combination of sleep dysfunction, neurodegeneration, and movement abnormalities. We report a case of a 62-year-old male who presented with excessive daytime sleepiness (EDS), bulbar weakness, and cognitive decline over three years. The patient exhibited REM sleep behavior disorder (RBD) with violent and complex movements during sleep, suggestive of a sleep-regulatory dysfunction. Clinical, polysomnographic, and serological findings strongly suggested anti-IgLON5 antibody disease. This case highlights the diagnostic challenges and the importance of early recognition and intervention in this emerging disorder

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Dr Paul Joy

Institution- Rajagiri Hospital,

Address Dept of Radio diagnosis, Rajagiri hospital, Aluva, Ernakulum district, kerala