Mammography is a widely used screening tool for breast cancer. While it has been shown to reduce mortality from breast cancer, its benefits and risks vary depending on the age group being screened. This paper aims to provide a comprehensive review of the benefits and risks of mammography screening specifically in women aged 40 to 49 years. The analysis includes statistical data, benefits in terms of early detection and mortality reduction, as well as the potential risks such as false positives, overdiagnosis, and radiation exposure.

Keywords

• Mammography screening
• Breast cancer
• Early detection
• Mortality reduction
• Women aged 40–49 years
• False positives
• Overdiagnosis
• Radiation exposure
• Breast-conserving surgery
• Psychological impact
• Risk assessment
• BRCA mutations
• Breast density
• Comparative effectiveness research
• Shared decision-making
• Screening guidelines
• Quality of life
• Anxiety and stress

            •           Treatment outcomes

1. Mammen D, Daniel M, Sane RT: Seasonal and Geographical Variations In Chemical Constituents of Leptadenia reticulate, International Journal of Pharmaceutical Sciences Review and Research, 2010 Volume 4, Issue 2
2. Anonymous: Soils, Plant Growth and Crop production- Medicinal and Aromatic Plants 2010, Volume II (Encyclopedia of Life Support Systems)
3. Shah Biren, Seth, A.K.: Drug Containing Alkaloids, Textbook of Pharmacognosy and Phytochemistry 2010, First edition, Elsevier Publication
4. Ali, M.: Alkaloids, Textbook of Pharmacognosy, 2007, CBS Publishers & Distributors
5. Kirtikar JD, Basu BD. Indian medicinal plants. Allahabad: Lalit Mohan Basu; 1994. pp. 1229–1231.
6. Research J. Pharmacognosy and Phytochemistry 2013; 5(3): 143-148 O. M. Singh, et al.
7. Abdollahi M, Karimpour H and Monsef – Esfehani H P, Antinociceptive effects of Teucrium polium L, total extract and essential oil in mouse writhing test, Pharmacology Research.48; 2003: 31- 35
8. Das S, Kumar P, Basu SP. Review article on phytoconstituents and therapeutic potentials of Daturastramonium linn. J Drug Del Therap. 2012;2(3):4–7.
9. Pretorius E, Marx J. Datura stramonium in asthma treatment and possible effects on prenatal development. Environ Toxicol Pharm. 2006;21(3):331–337
10. Taha SA, Mahdi AW. Datura intoxication in Riyadh. Trans R Soc Trop Med Hgy. 1984;78:134–135.
11. Takhi D, Ouinten M. Study of antimicrobial activity of secondary metabolites extracted from spontaneous plants from the area of Laghouat, Algeria. Adv EnvironmBiol. 2011;5(2):469–476.
12. Balachandran P, Rajgopal G. Cancer—an ayurve dicperspective. Pharm Res. 2005;51(1):19–30.
13. American Cancer Society. Breast Cancer Early Detection and Diagnosis. Updated 2023. Available at: https://www.cancer.org.
14. Marmot MG, Altman DG, Cameron DA, et al. The benefits and harms of breast cancer screening: an independent review. Lancet. 2012;380(9855):1778–1786. doi:10.1016/S0140-6736(12)61611-0
15. Nelson HD, Pappas M, Cantor A, et al. Harms of breast cancer screening: systematic review to update the 2009 U.S. Preventive Services Task Force Recommendation. Ann Intern Med. 2016;164(4):256–267. doi:10.7326/M15-0970
16. Miller AB, Wall C, Baines CJ, et al. Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ. 2014;348:g366. doi:10.1136/bmj.g366
17. Screening for Breast Cancer: Recommendations and Rationale. U.S. Preventive Services Task Force. 2016. https://www.uspreventiveservicestaskforce.org.
18. Siu AL, U.S. Preventive Services Task Force. Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2016;164(4):279–296. doi:10.7326/M15-2886
19. Tabár L, Vitak B, Chen HH, et al. Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer. 2001;91(9):1724–1731. doi:10.1002/1097-0142(20010501)91:9<1724::aid-cncr1195>3.0.co;2-w
20. Gøtzsche PC, Jørgensen KJ. Screening for breast cancer with mammography. Cochrane Database Syst Rev. 2013;2013(6):CD001877. doi:10.1002/14651858.CD001877.pub5
21. Coldman A, Phillips N, Wilson C, et al. Pan-Canadian Study of Mammography Screening and Mortality from Breast Cancer. J Natl Cancer Inst. 2014;106(11):dju261. doi:10.1093/jnci/dju261
22. Smith RA, Andrews K, Brooks D, et al. Cancer Screening in the United States, 2022: A Review of Current American Cancer Society Guidelines and Current Issues in Cancer Screening. CA Cancer J Clin. 2022;72(3):363–385. doi:10.3322/caac.21700
23. Nyström L, Andersson I, Bjurstam N, et al. Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet. 2002;359(9310):909–919. doi:10.1016/s0140-6736(02)07940-7
24. Brodersen J, Siersma VD. Long-term psychosocial consequences of false-positive screening mammography. Ann Fam Med. 2013;11(2):106–115. doi:10.1370/afm.1466
25. Lauby-Secretan B, Scoccianti C, Loomis D, et al. Breast-cancer screening — viewpoint of the IARC Working Group. N Engl J Med. 2015;372(24):2353–2358. doi:10.1056/NEJMsr1504363

Thamer Saeed Ali Alghamdi

Radiology Senior Specialist, Prince Mansour Military Hospital