Objectives: To evaluate the utilization of antihypertensive agents for the patients of Hypertension and subsequently their health outcome at a Tertiary Care Level Hospital and to observe the relationship among demographic profile of the patients.

Materials and Methods: An observational retrospective study was undertaken collecting total 680 patients’ data from patient admission ticket of a Tertiary Care Level Hospital. Mainly drugs used and outcome of the patients were recorded. Of all patients 306 were found to be treated with calcium channel blockers (CCBs), 77 with angiotensin receptor blockers (ARBs), 229 with CCBs plus ARBs, 46 with CCBs plus ARBs and beta blockers and only 22 patients got CCBs, ARBs and diuretics. Data were statistically analysed in respect of demographic profile, drugs used and clinical features of the patients.

Results: Best outcome was observed in patients treated with solely CCBs where in 289 out of 306 patients, hypertension was controlled. 194 out of 229 patients with CCBs and ARBs showed desired outcomes. 41 out of 77 with only ARBs, 29 out of 46 with CCBs, ARBs and beta blockers and 16 out of 22 with CCBs, ARBs and diuretics ended with positive results.

Conclusion: Calcium channel blockers alone and in few cases in combination with angiotensin receptor blocking agents are very effective in controlling hypertension.

Keywords: Hypertension, calcium channel blockers and angiotensin receptor blockers.

1. East L, Williams DS, Goldberg AC. Preventive Cardiology. The Washington Manual of Medical Therapeutics 37^th ed: 57-58
2. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC /NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/ American Heart Association task force on clinical practice guidelines. J Am Coll Cardiol. 2018; 1: e 127-e 248.
3. National Institute for Health Car Excellence. Hypertension in Adults: Diagnosis and Management. NICE Guideline 136. August ,2019.
4. Jones DW, Whelton PK, Allen N, et al. Management of Stage 1 hypertension in adults with a low 10 year risk for cardiovascular disease: filling a guidance gap- a scientific statement from the American Heart Association. 2021; 77: e 58- e67.
5. James PA, Oparil S, Carter BL, et al. 2014 Evidence – based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee. (JNC8). JAMA. 2014;311: 507-520
6. Alshami A, Romero C, Avila A, Varon J. Management of hypertensive crisis in elderly. J Geriatr Cardiol . 2018;15: 504-512.
7. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. Task Force Members. 2013 ESH/ESC guidelines for the management of arterial hypertension; the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) J Hypertens. 2013;31:1281–357.
8. Acquah, I, Hagan, K, Javed, Z, Taha, MB, Valero-Elizondo, J, Nwana, N, Yahya, T, Sharma, G, Gulati, M, Hammoud, A, et al. Social determinants of cardiovascular risk, subclinical cardiovascular disease, and cardiovascular events. J Am Heart Assoc. 2023;12: e025581. doi: 10.1161/JAHA.122.025581
9. Akinyelure, OP, Jaeger, BC, Oparil, S, Carson, AP, Safford, MM, Howard, G, Muntner, P, Hardy, ST. Social determinants of health and uncontrolled blood pressure in a national cohort of black and white US adults: the REGARDS study. Hypertension. 2023;80 :1403 –1413.
10. Braveman, P, Gottlieb, L. The social determinants of health: it’s time to consider the causes of the causes. Public Health Rep. 2014;129 :19–31.

Mithilesh Haldar

Department of Pharmacology and therapeutics, Burdwan Medical College and Hospital