Background:  An early pathogenic role for mitochondrial dysfunction in affected neurons, which occurs before morphological and functional abnormalities, is being supported by expanding information from studies on neurodegenerative diseases. Age is the primary risk factor for numerous diseases that affect people, the degenerative disorders are characterized by an abnormal protein accumulation, progressive loss of neuron cells, and impaired motor or cognitive abilities. One of the fundamental characteristics of aging is mitochondrial malfunction, especially in organs that need a lot of energy, such the heart, muscles, brain, or liver. Small amounts of ROS are produced by natural cell functions such aerobic respiration and inflammatory response mostly in macrophages and hepatocytes.

Aims: This review's objective is to introduce a fresh, innovative nanobiotechnological approach to medical care and issues related to neurodegenerative diseases.

Method: The pathophysiological foundations of the neurological disorders have a number of characteristics. Similarities include oxidative stress (OS) and inflammatory responses. Unfortunately, treating these disorders is difficult. Searches in the databases PubMed, Web of Science, Scopus, and the Cochrane Library found up relevant research on neurodegenerative diseases. The systematic review, which was based on a literature search.

Result: The resultant oxidative stress and respiratory dysfunction contribute to neuronal toxicity and may make neurons more susceptible to continuous attack by aggregation-prone proteins.

Conclusion: The advancements in science and technology of newly evolved materials at the nanoscale is known as nanotechnology, which is a fast growing discipline. Nanobiotechnology approaches, such as Nano delivery-based methodologies, are currently being researched to solve limitation such as  curcumin's stability bioavailability limitations.

Keywords:   Nanobiotech, Oxidative Stress, Neurodegenerative and Mitochondria.

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Tukur Zayyanu

Career Point University, Alaniya, Kota, Rajasthan, India