Background and Objective: Allergy is a defensive response of our body’s immune system, which presents itself in the form of various manifestations to indicate required intervention. Switching of allergy from its site of manifestations to a distant site within the body is called neurogenic switching concept. The objective of this study was to provide some observation the neurogenic switching concept of allergic manifestations during the course of Bakson’s Homoeopathic treatment.

Material and Method: An open-label observational retrospective study was undertaken among 52 patients who sought treatment for allergy at Bakson’s Homeopathic Center, South Extension; New Delhi. Case records which were included were of all those cases which were treated at least for six months during the calendar year 2020-2021.

Results: Out of 52 cases, 80% of cases, showed at least one neurogenic switching of allergy within the four systems. Over two-third cases of them had two or more times of switching during or end of the treatment. The switching of allergy commonly found from respiratory system to integumentary system. In majority of the cases switching is observed from integumentary to respiratory system. The calculated p value is much less than 0.001 and 0.039 by Pearson Chi-square and McNemar-Bowker Test respectively, shown the statistical significance of neurogenic switching of allergy during the course of treatment.

Conclusion: This study gives a clue in support of neurogenic switching of allergy with the concept of Allergy treatment at Bakson’s Homoeopathy. There is a need to undertake studies with greater sample size and randomized controlled trial to confirm the hypothesis scientifically.

Keywords: Bakson’s homoeopathy, Neurogenic switching, Allergy.

1. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee, Worldwide variation in prevalence of symptoms of asthma, allergic rhino conjunctivitis, and atopic eczema, Lancet, 351 (9111) (1998), pp. 1225-1232
2. F. BachThe effect of infections on susceptibility to autoimmune and allergic diseases N Engl J Med, 347 (12) (2002), pp. 911-920, 10.1056/NEJMra020100
3. K. Lai, R. Beasley, J. Crane, et al.Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC)Thorax, 64 (6) (2009), pp. 476-483, 10.1136/thx.2008.106609
4. Bjorksten, T. Clayton, P. Ellwood, A. Stewart, D. Strachan, I.P.I.S. GroupWorldwide time trends for symptoms of rhinitis and conjunctivitis: phase III of the international study of asthma and allergies in childhood. Pediatr Allergy Immunol, 19 (2) (2008), pp. 110-124, 10.1111/j.1399-3038.2007.00601.x
5. Prideaux, M.A. Kamm, P.P. De Cruz, F.K. Chan, S.C. NgInflammatory bowel disease in Asia: a systematic review.J Gastroenterol Hepatol, 27 (8) (2012), pp. 1266-1280, 10.1111/j.1440-1746.2012.07150.x
6. Papadakis M, McPhee S, Rabow M. Current medical diagnosis & treatment 2020. 59th ed. 2020.
7. Bellavite, Paolo. (2011). Advances in homeopathy and immunology a review of clinical research. Frontiers in Bioscience. S3. 1363-1389. 10.2741/s230.
8. Colin P. Homeopathy and respiratory allergies: a series of 147 cases. Homeopathy: The Journal of the Faculty of Homeopathy. 2006 Apr;95(2):68-72. DOI: 10.1016/j.homp.2006.01.003. PMID: 16569621.
9. Meggs WJ. Neurogenic switching: a hypothesis for a mechanism for switching the site of inflammation in allergy and chemical sensitivity. Environ Health Perspect. 1995 Jan;103(1):54-6. doi: 10.1289/ehp.9510354. PMID: 7628426; PMCID: PMC1519059.
10. Onorato J, Merland N, Terral C, Michel FB, Bousquet J. Placebo-controlled double-blind food challenge in asthma. J Allergy Clin Immunol 78:1139-1146 (1986).
11. Bousquet J, Chanez P, Michel F-B. The respiratory tract and food hypersensitivity. In: Food allergy: adverse reactions to foods and food additives (Metcalfe DD, Sampson HA, Simon RA, eds). Oxford: Blackwell Scientific Publications, 1991; 139-149.
12. Adkins FM. Food-induced urticaria. In: Food allergy: adverse reactions to foods and food additives (Metcalfe DD, Sampson HA, Simon RA, eds). Oxford: Blackwell Scientific Publications, 1991; 129-138.
13. Parke AL, Hughes GRV. Rheumatoid arthritis and food: a case study. Br Med J 282: 2027-2029 (1981).
14. Panush RS, Stroud RM, Webster EM. Food induced (allergic) arthritis: clinical and serological studies. Arthritis Rheum 29:220 (1986).
15. Egger J, Wilson J, Carter CM, Turner MW. Is migraine food allergy? A double-blind trial of oligoantigenic diet treatment. Lancet 2: 865-869 (1983).
16. Mansfield LE, Vaughan TR, Waller SF, Haverly RW, Ting S. Food allergy and adult migraine: double blind and mediator confirmation of an allergic etiology. Ann Allergy 55: 126-129 (1985).
17. Samuel H. Organon of Medicine. 5^th, 6^th ed. New Delhi: B. Jain Publishers; 1995. 

Dr Kathika Chattopadhyay

Chairperson, Research and Development Cell, Professor, HOD, Department of Psychiatry, Bakson Homoeopathic Medical College and Hospital, Greater Noida, Uttar Pradesh, India