Title: Co-infection with Hepatitis B virus (HBV) and Hepatitis C Virus (HCV) may Result in Asymptomatic Carrier Stage: A Case Report
Authors: Bandana Mehrotra, Ashok Kumar Kapoor, Hari Shyam, Atul Kumar Srivastava, Vasundhara Sharma, Supriya Mehrotra and Rajesh Kumar Srivastava
DOI: https://dx.doi.org/10.18535/jmscr/v11i1.07
Abstract
A 45-year-old male presented with mild loss of appetite. Serum total bilirubin was 1.2 mg/dl (reference range 0.1 to 1.0 mg/dl). Serum GOT was mildly raised to 56 (reference range 10-35 IU). Serum HBsAg was positive. Serum IgM anti-HCV antibody was also positive. The diagnosis of HBV and HCV co-infection was confirmed by Real-Time PCR. He was diagnosed as a case of asymptomatic HBV and HCV co-infection. Imbalance in the concentration of natural killer cells (NK dim and NK bright) might increase the necrosis of infected hepatocytes. Generation of cytotoxic T lymphocytes might eliminate both HBV and HCV, resulting in cell mediated immunity response and viral clearance.
References
- Iannacone M, Guidottic LG. Immunobiology and pathogenesis of hepatitis B virus infection. Nature reviews Immunology. Springer Nature Limited 2021.www nature.com/nri.
- Villas BN, Lyra PR, Venkatesha D. Coinfection of hepatitis B and hepatitis C virus among chronic liver disease (CLD) patients in tertiary care centre. Tropical J Path Microbiol 2018;4:12833.
- Mavilia MG, Wu GY. HBV-HCV coinfection: Viral interactions, management and viral reactivation. J Clin Transl Hepatol 2018; 6(3): 296 -305.
- Pol S, Haocur G, Fontaine H, Dorival C, Petrov-Sanchez V, Bourliere M, et al. The negative impact of HBV/HCV coinfection on cirrhosis and its consequences. Aliment Pharmacol Ther. 2017;46:1054-60.
- Lok ASF, McMahon BJ. Chronic hepatitis B. Hepatology 2007;45(2):507-39.
- Reddy GA, Dakshinamurthy KV, Neelaprasad P, Gangadhar T, Lakshmi V. Prevalence of HBV and HCV dual infection in patients on Haemodialysis 2005;23,41-43.
- Chakravarti A, Verma V, Jain M, Kar P. Characteristics of dual infection of hepatitis B and C viruses among patients with chronic liver disease: a study from tertiary care hospital. Trop Gastroenterol 2005; 26(4): 183-7.
- Kundu A, Mehta S, Agrawal BK. Prevalence of hepatitis B Virus and hepatitis C Virus among chronic liver disease patients in Northern Haryana region of India. JK Science 2015;17(4): 200-4.
- Yang D, Zuo C, Wang X, Meng X, Xue B, Liu N, et al. Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line. Proc Natl Acad Sci USA. 2014;111: e1264-e1273.
- Rios DA, Caciato PC, Caldirole MS, Gaillard MI, Giadans C, Ameigeiras B, et al. Chronic hepatitis C pathogenesis : immune response in the liver microenvironment and peripheral compartment. Front cell Inf Microbiol 2021, 1I ; article 712105.
- Cooper MA, Fehniger TA, Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol.2001;22, 633-640.