Aim: To study the correlation of urinary calcium-creatinine ratio in predicting pre-eclampsia in pregnant women.
Objectives

1. To study the urinary calcium:creatinine ratio among all pregnant women.
2. To correlate the urinary calcium: creatinine ratio in normotensive and pre-eclamptic women.

Methodology: This Prospective, observational study was conducted in the department of obstetrics and gynecology, Sri Ram MurtiSmarak Institute of Medical Sciences, Bareilly, India. Urinary calcium creatinine ratio was determined in a random sample of urine in 50  patients of pre-eclampsia (Study group) and 50 normotensive pregnant (Control group) patients of age 20-35 years with gestational age 20 weeks onwards. Cut off value for CCR was taken as ≤ 0.04.

Results: Out of 50 pre-eclamptic cases, 26(52%) cases in the study group had CCR ≤0.04 while only 7(14%) cases in control group had CCR ≤0.04 with a statistically significant p value of 0.000. On statistical analysis, CCR at ≤0.04 had a sensitivity of 52%, specificity of 86%, positive predictive value of 79% and negative predictive value of 64%. The accuracy of the test was 69%.

Conclusion: A single estimation of urinary calcium to creatinine ratio in asymptomatic pregnant women after 20 weeks of gestation is a simple and cost-effective test. A value of less than or equal to 0.04, in a spot urine sample, has a good predictive value for preeclampsia.

Keywords: Preeclampsia, Urinary Calcium, Urinary Creatinine, Urinary Calcium Creatinine ratio.

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Dr Anshika Agarwal