CML is “clonal hematopoietic disorder” caused by an acquired genetic defect in pluripotent stem cell, which is BCR –ABL protein which results from a reciprocal translocation involving chromosome 9 and 22 .The definite diagnosis of CML is obtained by demonstrating the presence of a BCR-ABL1 fusion. The cornerstone of CML treatment is represented by the use of TKIs utilized as monotherapy. The prognosis for CML changed so much with the introduction of cost effective drug “imatinib”, that today CML-related deaths are rare and a normal life expectancy is possible for CML patients.

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Dr Poonam Gupta -M.B.B.S- MD (Oncology)

Sr. Consultant –HPPCH Gorakhpur –India