Even though brain lymphatic system has several peculiarities including the construction of the endothelial cells of the lymph vessels, in common with the lymphatic system of the body in general, studies have documented eminent discrepancy. Unique lymphatic system of the brain is called ‘’the glymphatic system’’ due to its lymphatic system-like function and glial-like fluid flow. Collaboratory functions of this system, and CSF and interstitial fluid has been documented. Recent discovery of this system has highlighted the requirement to review the diagnose and treatment procedures of several neuronal diseases. With this discovery, anatomic, physiopathologic, immunologic, and genetic natures of this system have attracted attention of scientists. This review has summarized the accumulating information on the lymphatic system of the brain, particularly focusing on the function of the glymphatic system in fetus and newborn, cranial tumors, neurodegenerative diseases, brain metabolism and its relationship with sleep, and anatomical posture of the body. Yet, the cells responsible with the brain immune system and their relationship with the glymphatic system have been discussed. By summarizing the latest information on the relationship of this system with immunologic, molecular, physiologic, and anatomical aspects of several neuronaldiseases, this paper will surely contribute to the diagnose and treatment of them through shedding light on the researchers.

Keywords: Brain, Glymphatic System, Immunity, Neuronal Disease.

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Prof. Dr. Rengin Kosif

Kırıkkale University, Faculty of  Medicine, Department of Anatomy, Yahşihan/Kırıkkale, Türkiye