Cancer cells are those cells that overcomes the boundaries of impending unrestricted divisions and will multiply and further sustain aberrations that’s fuel its growth, survival, invasion and migration (metastasis) to established its presence in distant organs. Technologies have emerged that facilitate understanding of pathways which got disturbed leading the cause of cancer genesis it also opens the gate for targeted therapies that targets specific molecules in the pathways of cancer genesis and its further divisions like few examples , Gleeve which inhibits a subset of tyrosin kinase is approved for the treatment of CML,GIST tumors, Irresa which inhibits EGFR used in NSCLC, Herceptin an monoclonal antibody used in her-2 neu positive breast cancer treatment, Valcade, a Proteosome inhibitor that elicits programmed cell death is approved for the treatment of Multiple myeloma treatment .many more drugs are currently under trails .

Keywords: Targeted therapies, Metastasis, Migrations.

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Major Retd M.Q .Baig

Associate Professor, J.K Cancer institute Utter Pradesh Govt