Title: Prognostic Significance of Plasma Pseudocholinesterase Levels in Acute Organophosphorus Poisoning

Authors: Dr Kola Neelima, Dr Gagan Behari Behara, Dr K. Sudheer, Dr M. Madhusudan Babu

 DOI: https://dx.doi.org/10.18535/jmscr/v9i12.06

Abstract

Introduction

  • Organo Phosphorus poisoning was the most common in India due to its easy access. occupational or suicidal or homicidal exposure produce toxic effects, high mortality and morbidity.
  • OP compounds acts by inhibiting Acetylcholinesterase enzyme at nerve endings, neuromuscular junction causing overstimulation of Acetyl choline receptor. Signs and symptoms are mainly due to muscuranic, nicotinic and CNS receptor overstimulation.
  • In acute OP poisoning severity parallels the decrease in pseudocholinesterase activity.
  • Lab evaluation of pseudocholinesterase levels plays a crucial role in confirmation of poisoning and assessing the severity of OP poisoning.

Aims and Objectives

  1. To estimate the level of Plasma Pseudocholinesterase.
  2. To determine the association between level of Plasma Pseudocholinesterase and severity of Acute Organophosphorus poisoning.

References

  1. Amanvermez R, Baydın A, Yardan T, Başol N, Günay M. Emergency laboratory abnormalities in suicidal patients with acute organophosphate poisoning. Turkish J Biochem 2010;35:29-34.
  2. Manu MS, Prashant V, Akila P, Suma MN, Basavanagowdappa H. A retrospective analysis of serial measurement of serum cholinesterase in acute poisoning with organophosphate compounds. Toxicol Int 2012;19:255-9.
  3. Yun HW, Lee DH, Lee JH Cheon VJ, Choi YH. Serial serum Cholinesterase activities as a prognostic factor in organophosphate poisoned patients. Hong Kong J Emerg Med 2012;19:92-7.
  4. Amit Tyagi, AA Mehta, Rupal A Tyagi, Snehal Mehta. Oxidative stress and serum cholinesterase levels in organophosphorous poisoning.

Corresponding Author

Dr Kola Neelima

Gems & Hospital, Srikakulam, AP