Title: Prognostic Significance of Plasma Pseudocholinesterase Levels in Acute Organophosphorus Poisoning
Authors: Dr Kola Neelima, Dr Gagan Behari Behara, Dr K. Sudheer, Dr M. Madhusudan Babu
DOI: https://dx.doi.org/10.18535/jmscr/v9i12.06
Abstract
Introduction
- Organo Phosphorus poisoning was the most common in India due to its easy access. occupational or suicidal or homicidal exposure produce toxic effects, high mortality and morbidity.
- OP compounds acts by inhibiting Acetylcholinesterase enzyme at nerve endings, neuromuscular junction causing overstimulation of Acetyl choline receptor. Signs and symptoms are mainly due to muscuranic, nicotinic and CNS receptor overstimulation.
- In acute OP poisoning severity parallels the decrease in pseudocholinesterase activity.
- Lab evaluation of pseudocholinesterase levels plays a crucial role in confirmation of poisoning and assessing the severity of OP poisoning.
Aims and Objectives
- To estimate the level of Plasma Pseudocholinesterase.
- To determine the association between level of Plasma Pseudocholinesterase and severity of Acute Organophosphorus poisoning.
References
- Amanvermez R, Baydın A, Yardan T, Başol N, Günay M. Emergency laboratory abnormalities in suicidal patients with acute organophosphate poisoning. Turkish J Biochem 2010;35:29-34.
- Manu MS, Prashant V, Akila P, Suma MN, Basavanagowdappa H. A retrospective analysis of serial measurement of serum cholinesterase in acute poisoning with organophosphate compounds. Toxicol Int 2012;19:255-9.
- Yun HW, Lee DH, Lee JH Cheon VJ, Choi YH. Serial serum Cholinesterase activities as a prognostic factor in organophosphate poisoned patients. Hong Kong J Emerg Med 2012;19:92-7.
- Amit Tyagi, AA Mehta, Rupal A Tyagi, Snehal Mehta. Oxidative stress and serum cholinesterase levels in organophosphorous poisoning.