Introduction

• Organo Phosphorus poisoning was the most common in India due to its easy access. occupational or suicidal or homicidal exposure produce toxic effects, high mortality and morbidity.
• OP compounds acts by inhibiting Acetylcholinesterase enzyme at nerve endings, neuromuscular junction causing overstimulation of Acetyl choline receptor. Signs and symptoms are mainly due to muscuranic, nicotinic and CNS receptor overstimulation.
• In acute OP poisoning severity parallels the decrease in pseudocholinesterase activity.
• Lab evaluation of pseudocholinesterase levels plays a crucial role in confirmation of poisoning and assessing the severity of OP poisoning.

Aims and Objectives

1. To estimate the level of Plasma Pseudocholinesterase.
2. To determine the association between level of Plasma Pseudocholinesterase and severity of Acute Organophosphorus poisoning.

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Dr Kola Neelima

Gems & Hospital, Srikakulam, AP