Title: Cytohistological Correlative Study of Thyroid Lesions by Imprint Method
Authors: Anjali PV, Nataraju G
DOI: https://dx.doi.org/10.18535/jmscr/v9i12.02
Abstract
Background: Thyroid disorders are common clinical problem which are unique in both clinical presentation and symptoms. Imprint cytology is a simple, inexpensive and rapid diagnostic procedure that can be used in the perioperative diagnosis of thyroid lesions. The current study is designed to study the age, sex profile and the spectrum of various thyroid lesions and to assess the efficacy of imprint cytology by comparing it with histopathology smears.
Method: In our study, conducted over a period of 18 months, imprint cytology of thyroid lesions was done perioperatively. The histopathological diagnosis was considered as the gold standard and imprint cytological diagnosis was compared with it.
Results: In the present study, age of the patient ranged from 14-70 years, with a mean age being 39.24 years. Majority of patients were females with male to female ratio of 1:7.8. Out of the 53 cases studied, 46 cases were diagnosed as benign and7cases were diagnosed as malignant on imprint cytology. On histopathological examination, 45cases were diagnosed as benign and 8 cases were diagnosed as malignant. On cytohistopathological correlation, sensitivity and specificity was found to be 87.5 % and 100% respectively. The positive predictive value, negative predictive value and diagnostic accuracy was found to be 100%, 97.8% and 98.1% respectively.
Conclusion: Imprint cytology is a simple, cost effective and rapid intraoperative diagnostic technique which can be a useful guide in making intraoperative therapeutic decision quickly.
Keywords: Thyroid, Imprint cytology, Histopathology, Colloid goitre, Papillary Thyroid Carcinoma, accuracy
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